Uterine extracellular matrix (ECM) remodeling occurs throughout pregnancy and at parturition. Imbalanced availability of key mediators in ECM degradation, namely, matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs), is implicated in the pathogenesis of preterm labor (PTL).
Expression of Matrix Metalloproteinases in the Mouse Uterus and Human Myometrium During Pregnancy, Labor, and Preterm Labor / Lombardi, Annalia; Makieva, Sofia; Rinaldi, Sara F; Arcuri, Felice; Petraglia, Felice; Norman, Jane E. - In: REPRODUCTIVE SCIENCES. - ISSN 1933-7191. - ELETTRONICO. - (2017), pp. 1933719117732158-1933719117732158. [10.1177/1933719117732158]
Expression of Matrix Metalloproteinases in the Mouse Uterus and Human Myometrium During Pregnancy, Labor, and Preterm Labor
Petraglia, Felice;
2017
Abstract
Uterine extracellular matrix (ECM) remodeling occurs throughout pregnancy and at parturition. Imbalanced availability of key mediators in ECM degradation, namely, matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs), is implicated in the pathogenesis of preterm labor (PTL).
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