In melanoma cells, LMW-PTP modulates sensitivity to chemio- and radiotherapy. LMW-PTP targeting with Morin, a natural inhibitor of this phosphatase, enhances effectiveness of dacarbazine and radiotherapy treatment, and reduce self-renewal ability of melanoma, without affecting viability of normal cells. In conclusion, Morin behaves as a potent, no toxic, sensitizing agent.

Targeting LMW-PTP to sensitize melanoma cancer cells toward chemo- and radiotherapy / Giulia Lori, Paolo Paoli, Anna Caselli, Paolo Cirri, Riccardo Marzocchini, Monica Mangoni, Cinzia Talamonti, Lorenzo Livi, Giovanni Raugei.. - In: CANCER MEDICINE. - ISSN 2045-7634. - ELETTRONICO. - 7:(2018), pp. 1933-1943. [10.1002/cam4.1435]

Targeting LMW-PTP to sensitize melanoma cancer cells toward chemo- and radiotherapy.

LORI, GIULIA
Membro del Collaboration Group
;
Paolo Paoli
Membro del Collaboration Group
;
Anna Caselli
Membro del Collaboration Group
;
Paolo Cirri
Writing – Review & Editing
;
Riccardo Marzocchini
Writing – Review & Editing
;
Monica Mangoni
Membro del Collaboration Group
;
Cinzia Talamonti
Resources
;
Lorenzo Livi
Writing – Review & Editing
;
Giovanni Raugei.
Supervision
2018

Abstract

In melanoma cells, LMW-PTP modulates sensitivity to chemio- and radiotherapy. LMW-PTP targeting with Morin, a natural inhibitor of this phosphatase, enhances effectiveness of dacarbazine and radiotherapy treatment, and reduce self-renewal ability of melanoma, without affecting viability of normal cells. In conclusion, Morin behaves as a potent, no toxic, sensitizing agent.
2018
7
1933
1943
Giulia Lori, Paolo Paoli, Anna Caselli, Paolo Cirri, Riccardo Marzocchini, Monica Mangoni, Cinzia Talamonti, Lorenzo Livi, Giovanni Raugei.
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1113812
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