Targeting LMW-PTP to sensitize melanoma cancer cells toward chemo- and radiotherapy.

In melanoma cells, LMW-PTP modulates sensitivity to chemio- and radiotherapy. LMW-PTP targeting with Morin, a natural inhibitor of this phosphatase, enhances effectiveness of dacarbazine and radiotherapy treatment, and reduce self-renewal ability of melanoma, without affecting viability of normal cells. In conclusion, Morin behaves as a potent, no toxic, sensitizing agent.