Progressive functional decline in the epilepsies is largely unexplained. We formed the ENIGMA-Epilepsy consortium to understand factors that influence brain measures in epilepsy, pooling data from 24 research centres in 14 countries across Europe, North and South America, Asia, and Australia. Structural brain measures were extracted from MRI brain scans across 2149 individuals with epilepsy, divided into four epilepsy subgroups including idiopathic generalized epilepsies (n =367), mesial temporal lobe epilepsies with hippocampal sclerosis (MTLE; left, n = 415; right, n = 339), and all other epilepsies in aggregate (n = 1026), and compared to 1727 matched healthy controls. We ranked brain structures in order of greatest differences between patients and controls, by meta-analysing effect sizes across 16 subcortical and 68 cortical brain regions. We also tested effects of duration of disease, age at onset, and age-by-diagnosis interactions on structural measures. We observed widespread patterns of altered subcortical volume and reduced cortical grey matter thickness.
Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study / Whelan CD, Altmann A, Botía JA, Jahanshad N, Hibar DP, Absil J, Alhusaini S, Alvim MKM, Auvinen P, Bartolini E,Bergo FPG, Bernardes T, Blackmon K,Braga B, Caligiuri ME, Calvo A, Carr SJ, Chen J, Chen S,Cherubini A, David P, Domin M, Foley S, França W, Haaker G,Isaev D, Keller SS, Kotikalapudi R, Kowalczyk MA, Kuzniecky R, Langner S, Lenge M, Leyden KM,Liu M, Loi RQ,Martin P, Mascalchi M,Morita ME, Pariente JC, Rodríguez-Cruces R, Rummel C, Saavalainen T, Semmelroch MK, Severino M, Thomas RH,Tondelli M, Tortora D, Vaudano AE39, Vivash L40,41, von Podewils F42, Wagner J43,44, Weber B43,45, Yao Y46, Yasuda CL7, Zhang G47, Bargalló N15,48, Bender B26, Bernasconi N, Bernasconi A, Bernhardt BC,Blümcke I, Carlson C,Cavalleri GL,Cendes F, Concha L, Delanty N, Depondt C, Devinsky O, Doherty CP51,54, Focke NK, Gambardella A, Guerrini R, Hamandi K, Jackson GD, Kälviäinen R, Kochunov P, Kwan P, Labate A, McDonald CR, Meletti S, O'Brien TJ,Ourselin S, Richardson MP Striano P, Thesen T, Wiest R, Zhang J, Vezzani A, Ryten M, Thompson PM, Sisodiya SM.. - In: BRAIN. - ISSN 0006-8950. - STAMPA. - (2018), pp. 391-408. [10.1093/brain/awx341]
Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study
Mascalchi M;Guerrini R;
2018
Abstract
Progressive functional decline in the epilepsies is largely unexplained. We formed the ENIGMA-Epilepsy consortium to understand factors that influence brain measures in epilepsy, pooling data from 24 research centres in 14 countries across Europe, North and South America, Asia, and Australia. Structural brain measures were extracted from MRI brain scans across 2149 individuals with epilepsy, divided into four epilepsy subgroups including idiopathic generalized epilepsies (n =367), mesial temporal lobe epilepsies with hippocampal sclerosis (MTLE; left, n = 415; right, n = 339), and all other epilepsies in aggregate (n = 1026), and compared to 1727 matched healthy controls. We ranked brain structures in order of greatest differences between patients and controls, by meta-analysing effect sizes across 16 subcortical and 68 cortical brain regions. We also tested effects of duration of disease, age at onset, and age-by-diagnosis interactions on structural measures. We observed widespread patterns of altered subcortical volume and reduced cortical grey matter thickness.
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