Gluten-induced aggregation of K562 cells represents an in vitro model reproducing the early steps occurring in the small bowel of celiac patients exposed to gliadin. Despite the clear involvement of TG2 in the activation of the antigen-presenting cells, it is not yet clear in which compartment it occurs. Herein we study the calcium-dependent aggregation of these cells, using either cell-permeable or cell-impermeable TG2 inhibitors.
Involvement of cell surface TG2 in the aggregation of K562 cells triggered by gluten / Feriotto G, C.R.. - In: AMINO ACIDS. - ISSN 0939-4451. - STAMPA. - (2017), pp. 551-565. [10.1007/s00726-016-2339-4]
Involvement of cell surface TG2 in the aggregation of K562 cells triggered by gluten
Guerrini R;
2017
Abstract
Gluten-induced aggregation of K562 cells represents an in vitro model reproducing the early steps occurring in the small bowel of celiac patients exposed to gliadin. Despite the clear involvement of TG2 in the activation of the antigen-presenting cells, it is not yet clear in which compartment it occurs. Herein we study the calcium-dependent aggregation of these cells, using either cell-permeable or cell-impermeable TG2 inhibitors.
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