: ACE gene is reported to be a candidate gene in heart failure. The insertion/deletion (I/D) polymorphism has been observed to be a predictor of mortality in this disease, but no data are available concerning the role of ACE -240A>T polymorphism. In this study, we investigated the role of ACE I/D and -240A>T polymorphisms in influencing both severity and clinical outcomes in patients with heart failure, according to New York Heart Association (NYHA) class.
ACE insertion/deletion, but not -240A>T polymorphism, modulates the severity in heart failure / Fatini, Cinzia; Sticchi, Elena; Marcucci, Rossella; Said, Abdihakim Abdullahi; Del Pace, Stefano; Verdiani, Valerio; Nozzoli, Carlo; Gensini, Gian Franco; Abbate, Rosanna. - In: JOURNAL OF INVESTIGATIVE MEDICINE. - ISSN 1081-5589. - STAMPA. - 56:(2008), pp. 1004-1010. [10.2310/JIM.0b013e31818e8028]
ACE insertion/deletion, but not -240A>T polymorphism, modulates the severity in heart failure
Fatini, Cinzia;Sticchi, Elena;Marcucci, Rossella;ABDULLAHI, SAID ABDIHAKIM;Gensini, Gian Franco;Abbate, Rosanna
2008
Abstract
: ACE gene is reported to be a candidate gene in heart failure. The insertion/deletion (I/D) polymorphism has been observed to be a predictor of mortality in this disease, but no data are available concerning the role of ACE -240A>T polymorphism. In this study, we investigated the role of ACE I/D and -240A>T polymorphisms in influencing both severity and clinical outcomes in patients with heart failure, according to New York Heart Association (NYHA) class.
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