BACKGROUND: In HCV-infected cirrhotic patients with successfully treated early hepatocellular carcinoma (HCC), the time to HCC recurrence and the effects of sustained viral eradication (SVR) by interferon (IFN)-based or IFN-free regimens on HCC recurrence remain unclear. AIM: To perform an indirect comparison of time to recurrence (TTR) in patients with successfully treated early HCC and active HCV infection with those of patients with SVR by IFN-based and by IFN-free regimens. METHODS: We evaluated 443 patients with HCV-related cirrhosis and Barcelona Clinic Liver Cancer Stage A/0 HCC who had a complete radiological response after curative resection or ablation. Active HCV infection was present in 328, selected from the Italian Liver Cancer group cohort; 58 patients had SVR achieved by IFN-free regimens after HCC cure, and 57 patients had SVR achieved by IFN-based regimens after HCC cure. Individual data of patients in the last two groups were extracted from available publications. RESULTS: TTR by Kaplan-Meier curve was significantly lower in patients with active HCV infection compared with those with SVR both by IFN-free (P = 0.02) and by IFN-based (P < 0.001) treatments. TTR was similar in patients with SVR by IFN-free or by IFN-based (P = 0.49) strategies. CONCLUSION: In HCV-infected, successfully treated patients with early HCC, SVR obtained by IFN-based or IFN-free regimens significantly reduce tumour recurrence without differences related to the anti-viral strategy used.

Hepatocellular carcinoma recurrence in patients with curative resection or ablation: impact of HCV eradication does not depend on the use of interferon / Petta, S.; Cabibbo, G.; Barbara, M.; Attardo, S.; Bucci, L.; Farinati, F.; Giannini, E.G.; Tovoli, F.; Ciccarese, F.; Rapaccini, G.L.; Di Marco, M.; Caturelli, E.; Zoli, M.; Borzio, F.; Sacco, R.; Virdone, R.; Marra, F.; Felder, M.; Morisco, F.; Benvegnù, L.; Gasbarrini, A.; Svegliati-Baroni, G.; Foschi, F.G.; Olivani, A.; Masotto, A.; Nardone, G.; Colecchia, A.; Persico, M.; Boccaccio, V.; Craxì, A.; Bruno, S.; Trevisani, F.; Cammà, C; Biselli, Maurizio; Caraceni, Paolo; Cucchetti, Alessandro; Domenicali, Marco; Piscaglia, Fabio; Gramenzi, Annagiulia; Granito, Alessandro; Magalotti, Donatella; Serra, Carla; Negrini, Giulia; Napoli, L.; Napoli, Lucia; Salvatore, Veronica; Benevento, Francesca; Gazzola, Alessia; Murer, Francesca; Pozzan, Caterina; Vanin, Veronica; Moscatelli, Alessandro; Pellegatta, Gaia; Picciotto, Antonino; Savarino, Vincenzo; Delpoggio, Paolo; Olmi, Stefano; Dematthaeis, Nicoletta; Balsamo, Claudia; Vavassori, Elena; Roselli, Paola; Dell’Isola, Serena; Ialungo, Anna Maria; Rastrelli, Elena; Rini, Francesca; Costantino, Andrea; Affronti, Andrea; Affronti, Marco; Mascari, Marta; Mega, Andrea; Pompili, Maurizio; Rinninella, Emanuele; Mismas, Valeria; Dall’Aglio, Anna Chiara; Feletti, Valentina; Lanzi, Arianna; Cappa, Federica Mirici; Neri, Elga; Stefanini, Giuseppe Francesco; Tamberi, Stefano; Biasini, Elisabetta; Missale, Gabriele; Guarino, Maria; Ortolani, Alessio; Chiaramonte, Maria; Marchetti, Fabiana; Valerio, Matteo; Aburas, Sami; Inghilesi, Andrea L.; Cappelli, Alberta; Golfieri, Rita; Mosconi, Cristina; Renzulli, Matteo; Coccoli, Piero; Zamparelli, Marco Sanduzzi; Petta, Salvatore; Cabibbo, Giuseppe; Barbara, Marco; Attardo, Simona; Bucci, Laura; Farinati, Fabio; Giannini, Edoardo G.; Tovoli, Francesco; Ciccarese, Francesca; Rapaccini, Gian Lodovico; Dimarco, Maria; Caturelli, Eugenio; Zoli, Marco; Borzio, Franco; Sacco, Rodolfo; Virdone, Roberto; Marra, Fabio; Felder, Martina; Morisco, Filomena; Benvegnù, Luisa; Gasbarrini, Antonio; Svegliati-Baroni, Gianluca; Foschi, Francesco Giuseppe; Olivani, Andrea; Masotto, Alberto; Nardone, Gerardo; Colecchia, Antonio; Persico, Marcello; Boccaccio, Vincenzo; Craxì, Antonio; Bruno, Savino; Trevisani, Franco; Cammà, Calogero. - In: ALIMENTARY PHARMACOLOGY & THERAPEUTICS. - ISSN 0269-2813. - STAMPA. - 45:(2017), pp. 160-168. [10.1111/apt.13821]

Hepatocellular carcinoma recurrence in patients with curative resection or ablation: impact of HCV eradication does not depend on the use of interferon

Aburas, Sami;INGHILESI, ANDREA LORENZO;MARRA, FABIO;
2017

Abstract

BACKGROUND: In HCV-infected cirrhotic patients with successfully treated early hepatocellular carcinoma (HCC), the time to HCC recurrence and the effects of sustained viral eradication (SVR) by interferon (IFN)-based or IFN-free regimens on HCC recurrence remain unclear. AIM: To perform an indirect comparison of time to recurrence (TTR) in patients with successfully treated early HCC and active HCV infection with those of patients with SVR by IFN-based and by IFN-free regimens. METHODS: We evaluated 443 patients with HCV-related cirrhosis and Barcelona Clinic Liver Cancer Stage A/0 HCC who had a complete radiological response after curative resection or ablation. Active HCV infection was present in 328, selected from the Italian Liver Cancer group cohort; 58 patients had SVR achieved by IFN-free regimens after HCC cure, and 57 patients had SVR achieved by IFN-based regimens after HCC cure. Individual data of patients in the last two groups were extracted from available publications. RESULTS: TTR by Kaplan-Meier curve was significantly lower in patients with active HCV infection compared with those with SVR both by IFN-free (P = 0.02) and by IFN-based (P < 0.001) treatments. TTR was similar in patients with SVR by IFN-free or by IFN-based (P = 0.49) strategies. CONCLUSION: In HCV-infected, successfully treated patients with early HCC, SVR obtained by IFN-based or IFN-free regimens significantly reduce tumour recurrence without differences related to the anti-viral strategy used.
2017
45
160
168
Petta, S.; Cabibbo, G.; Barbara, M.; Attardo, S.; Bucci, L.; Farinati, F.; Giannini, E.G.; Tovoli, F.; Ciccarese, F.; Rapaccini, G.L.; Di Marco, M.; Caturelli, E.; Zoli, M.; Borzio, F.; Sacco, R.; Virdone, R.; Marra, F.; Felder, M.; Morisco, F.; Benvegnù, L.; Gasbarrini, A.; Svegliati-Baroni, G.; Foschi, F.G.; Olivani, A.; Masotto, A.; Nardone, G.; Colecchia, A.; Persico, M.; Boccaccio, V.; Craxì, A.; Bruno, S.; Trevisani, F.; Cammà, C; Biselli, Maurizio; Caraceni, Paolo; Cucchetti, Alessandro; Domenicali, Marco; Piscaglia, Fabio; Gramenzi, Annagiulia; Granito, Alessandro; Magalotti, Donatella; Serra, Carla; Negrini, Giulia; Napoli, L.; Napoli, Lucia; Salvatore, Veronica; Benevento, Francesca; Gazzola, Alessia; Murer, Francesca; Pozzan, Caterina; Vanin, Veronica; Moscatelli, Alessandro; Pellegatta, Gaia; Picciotto, Antonino; Savarino, Vincenzo; Delpoggio, Paolo; Olmi, Stefano; Dematthaeis, Nicoletta; Balsamo, Claudia; Vavassori, Elena; Roselli, Paola; Dell’Isola, Serena; Ialungo, Anna Maria; Rastrelli, Elena; Rini, Francesca; Costantino, Andrea; Affronti, Andrea; Affronti, Marco; Mascari, Marta; Mega, Andrea; Pompili, Maurizio; Rinninella, Emanuele; Mismas, Valeria; Dall’Aglio, Anna Chiara; Feletti, Valentina; Lanzi, Arianna; Cappa, Federica Mirici; Neri, Elga; Stefanini, Giuseppe Francesco; Tamberi, Stefano; Biasini, Elisabetta; Missale, Gabriele; Guarino, Maria; Ortolani, Alessio; Chiaramonte, Maria; Marchetti, Fabiana; Valerio, Matteo; Aburas, Sami; Inghilesi, Andrea L.; Cappelli, Alberta; Golfieri, Rita; Mosconi, Cristina; Renzulli, Matteo; Coccoli, Piero; Zamparelli, Marco Sanduzzi; Petta, Salvatore; Cabibbo, Giuseppe; Barbara, Marco; Attardo, Simona; Bucci, Laura; Farinati, Fabio; Giannini, Edoardo G.; Tovoli, Francesco; Ciccarese, Francesca; Rapaccini, Gian Lodovico; Dimarco, Maria; Caturelli, Eugenio; Zoli, Marco; Borzio, Franco; Sacco, Rodolfo; Virdone, Roberto; Marra, Fabio; Felder, Martina; Morisco, Filomena; Benvegnù, Luisa; Gasbarrini, Antonio; Svegliati-Baroni, Gianluca; Foschi, Francesco Giuseppe; Olivani, Andrea; Masotto, Alberto; Nardone, Gerardo; Colecchia, Antonio; Persico, Marcello; Boccaccio, Vincenzo; Craxì, Antonio; Bruno, Savino; Trevisani, Franco; Cammà, Calogero
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1119452
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