The competitive binding between CpG-ODN (single-stranded DNA from pathogens) and HLA-B and HLA-A ligands for the inhibitory Killer Immunoglobulin-like Receptors (KIR)3DL1/2 may lead to possible hypo-sensing of pathogens and ineffective clearance. We observed an overabundance of HLA ligands for inhibitory KIR with three domains in KD subjects.
An immune-molecular hypothesis supporting infectious aetiopathogenesis of Kawasaki disease in children / Capittini, Cristina*; Emmi, Giacomo; Mannarino, Savina; Bossi, Grazia; Dellepiane, Rosa Maria; Salice, Patrizia; Pietrogrande, Maria Cristina; Pasi, Annamaria; De Silvestri, Annalisa; Tinelli, Carmine; Martinetti, Miryam. - In: EUROPEAN JOURNAL OF IMMUNOLOGY. - ISSN 0014-2980. - ELETTRONICO. - 48:(2018), pp. 543-545. [10.1002/eji.201747226]
An immune-molecular hypothesis supporting infectious aetiopathogenesis of Kawasaki disease in children
Emmi, Giacomo;PIETROGRANDE, MARIA CRISTINA;
2018
Abstract
The competitive binding between CpG-ODN (single-stranded DNA from pathogens) and HLA-B and HLA-A ligands for the inhibitory Killer Immunoglobulin-like Receptors (KIR)3DL1/2 may lead to possible hypo-sensing of pathogens and ineffective clearance. We observed an overabundance of HLA ligands for inhibitory KIR with three domains in KD subjects.
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