Question What is the long-term outcome of pediatric-onset hypertrophic cardiomyopathy, and are there age-specific risk factors for lethal arrhythmic events? Findings In this cohort study, 24 of 100 patients with hypertrophic cardiomyopathy diagnosed between age 1 and 16 years had major events in 9.2 years (mean rate, 1.9%per year), including 19 lethal arrhythmic events (at a mean [SD] age of 23.1 [11.5] years and up to 33 years after diagnosis) and 5 heart failure–related events. Risk was predicted by limiting symptoms at initial evaluation and Troponin I or T gene mutations. Meaning Pediatric-onset hypertrophic cardiomyopathy is characterized by adverse outcomes driven mainly by arrhythmic events; risk extends well beyond adolescence, requiring unchanged levels of surveillance into adulthood, and predictors of risk in this age group differ from those of adult populations

Long-term Outcomes of Pediatric-Onset Hypertrophic Cardiomyopathy and Age-Specific Risk Factors for Lethal Arrhythmic Events / Niccolò Maurizi, Silvia Passantino, Gaia Spaziani, Francesca Girolami, Anna Arretini, Mattia Targetti, Iva Pollini, Alessia Tomberli, Silvia Pradella, Giovanni Battista Calabri, Veronica Vinattieri, Bruno Bertaccini, Ornella Leone, Luciano De Simone, Claudio Rapezzi, Niccolò Marchionni, Franco Cecchi, Silvia Favilli, Iacopo Olivotto. - In: JAMA CARDIOLOGY. - ISSN 2380-6583. - STAMPA. - ...:(2018), pp. 0-0. [10.1001/jamacardio.2018.0789]

Long-term Outcomes of Pediatric-Onset Hypertrophic Cardiomyopathy and Age-Specific Risk Factors for Lethal Arrhythmic Events

Niccolò Maurizi;Silvia Passantino;Gaia Spaziani;Francesca Girolami;Anna Arretini;Mattia Targetti;Alessia Tomberli;Silvia Pradella;Veronica Vinattieri;Bruno Bertaccini;Niccolò Marchionni;Franco Cecchi;Silvia Favilli;Iacopo Olivotto
2018

Abstract

Question What is the long-term outcome of pediatric-onset hypertrophic cardiomyopathy, and are there age-specific risk factors for lethal arrhythmic events? Findings In this cohort study, 24 of 100 patients with hypertrophic cardiomyopathy diagnosed between age 1 and 16 years had major events in 9.2 years (mean rate, 1.9%per year), including 19 lethal arrhythmic events (at a mean [SD] age of 23.1 [11.5] years and up to 33 years after diagnosis) and 5 heart failure–related events. Risk was predicted by limiting symptoms at initial evaluation and Troponin I or T gene mutations. Meaning Pediatric-onset hypertrophic cardiomyopathy is characterized by adverse outcomes driven mainly by arrhythmic events; risk extends well beyond adolescence, requiring unchanged levels of surveillance into adulthood, and predictors of risk in this age group differ from those of adult populations
2018
...
0
0
Niccolò Maurizi, Silvia Passantino, Gaia Spaziani, Francesca Girolami, Anna Arretini, Mattia Targetti, Iva Pollini, Alessia Tomberli, Silvia Pradella, Giovanni Battista Calabri, Veronica Vinattieri, Bruno Bertaccini, Ornella Leone, Luciano De Simone, Claudio Rapezzi, Niccolò Marchionni, Franco Cecchi, Silvia Favilli, Iacopo Olivotto
File in questo prodotto:
File Dimensione Formato  
Maurizi_JAMA Cardiol 2018.pdf

Accesso chiuso

Tipologia: Pdf editoriale (Version of record)
Licenza: DRM non definito
Dimensione 280.38 kB
Formato Adobe PDF
280.38 kB Adobe PDF   Richiedi una copia

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1121936
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 72
  • ???jsp.display-item.citation.isi??? 61
social impact