Prescription and Delivery of the Right Continuous Renal Replacement Therapies Dose

This chapter focuses on the definitions and impact of prescription and delivery of the right dose of treatment in patients on continuous renal replacement therapy (CRRT). We define "dose" and the concepts of efficiency, intensity, and efficacy; differentiate their multiple components; and describe the practical application of those concepts to direct patient care. In the article, we emphasize the effects of delivered dose variation on solute control, and list the main factors affecting CRRT dose delivery. Finally, we summarize the main indicators of dose monitoring and emphasize the importance of an excellent quality control system to ensure appropriate delivery of care to critically ill patients with acute kidney injury.