In neuro Behçet disease with multiple sclerosis‐like features, diagnosis could be challenging. Here, we studied the cerebrospinal fluid and serum inflammatory profile of 11 neuro Behçet and 21 relapsing‐remitting multiple sclerosis patients. Between the soluble factors analyzed (MMP9, TNFα, IL6, CXCL13, CXCL10, CXCL8, IFNγ, IL10, IL17, IL23, and others) we found MMP9 increased in neuro Behçet serum compared to multiple sclerosis and decreased in cerebrospinal fluid. Furthermore, neuro Behçet analysis of circulating natural killer CD56DIM subset suggests their potential involvement in increased MMP9 production. We believe that these findings may have a translational utility in clinical practice.

CSF/serum matrix metallopeptidase‐9 ratio discriminates neuro Behçet from multiple sclerosis / Aldinucci A, Bonechi E, Biagioli T, Repice AM, D'Elios MM, Emmi L, Emmi G, Silvestri E, Barilaro A, Ballerini C. - In: ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY. - ISSN 2328-9503. - ELETTRONICO. - (2018), pp. 1-6. [10.1002/acn3.538]

CSF/serum matrix metallopeptidase‐9 ratio discriminates neuro Behçet from multiple sclerosis

Aldinucci A;Bonechi E;Biagioli T;Repice AM;D'Elios MM;Emmi G;Silvestri E;Barilaro A;Ballerini C
2018

Abstract

In neuro Behçet disease with multiple sclerosis‐like features, diagnosis could be challenging. Here, we studied the cerebrospinal fluid and serum inflammatory profile of 11 neuro Behçet and 21 relapsing‐remitting multiple sclerosis patients. Between the soluble factors analyzed (MMP9, TNFα, IL6, CXCL13, CXCL10, CXCL8, IFNγ, IL10, IL17, IL23, and others) we found MMP9 increased in neuro Behçet serum compared to multiple sclerosis and decreased in cerebrospinal fluid. Furthermore, neuro Behçet analysis of circulating natural killer CD56DIM subset suggests their potential involvement in increased MMP9 production. We believe that these findings may have a translational utility in clinical practice.
2018
1
6
Goal 3: Good health and well-being for people
Aldinucci A, Bonechi E, Biagioli T, Repice AM, D'Elios MM, Emmi L, Emmi G, Silvestri E, Barilaro A, Ballerini C
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1123640
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