Ultrafine particles (UFPs) from domestic wood stoves: genotoxicity in human lung carcinoma A549 cells

Marabini, L.; Ozgen, S.; Turacchi, S.; Aminti, S.; Arnaboldi, F.; Lonati, G.; Fermo, P.; Corbella, L.; Valli, G.; Bernardoni, V.; Dell'Acqua, M.; Vecchi, R.; Becagli, S.; Caruso, D.; Corrado, L. G.; Marinovich, M.

doi:10.1016/j.mrgentox.2017.06.001

In this paper, results on the potential toxicity of ultraﬁne particles (UFPs d < 100 nm) emitted by the combustion of logwood and pellet (hardwood and softwood) are reported. The data were collected during the TOBICUP (TOxicity of BIomass COmbustion generated Ultraﬁne Particles) project, carried out by a team composed of interdisciplinary research groups. The genotoxic evaluation was performed on A549 cells (human lung carcinomacells) using UFPs whose chemical composition was assessed by a suite of analytical techniques. Comet assay and γ-H2AX evaluation show a signiﬁcant DNA damage after 24 h treatment. The interpretation of the results is based on the correlation among toxicological results, chemical-physical properties of UFPs, and the type and eﬃciency conditions in residential pellet or logwood stoves.

Ultrafine particles (UFPs) from domestic wood stoves: genotoxicity in human lung carcinoma A549 cells / Marabini, L., Ozgen, S., Turacchi, S., Aminti, S., Arnaboldi, F., Lonati, G., Fermo, P., Corbella, L., Valli, G., Bernardoni, V., Dell'Acqua, M., Vecchi, R., Becagli, S., Caruso, D., Corrado, L.G., Marinovich, M.. - In: MUTATION RESEARCH. GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS. - ISSN 1383-5718. - ELETTRONICO. - (2017), pp. 39-46. [10.1016/j.mrgentox.2017.06.001]