Some frozen analogues of 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP) and of 1-(3-pyridyl)piperazine have been synthesized and tested on rat cerebral cortex by means of binding studies. Among the synthesized substances, only compound 2c was found to displace [3H]-cytisine from the nicotinic binding sites on rat cerebral cortex. Some possible explanations for the inactivity of the other compounds are given
DESIGN, SYNTHESIS AND PRELIMINARY PHARMACOLOGICAL EVALUATION OF RIGID ANALOGUES OF THE NICOTINIC AGONIST 1,1-DIMETHYL-4-PHENYLPIPERAZINIUM IODIDE (DMPP) / L. GUANDALINI; E. MARTINI; F. GUALTIERI; M. ROMANELLI; K. VARANI. - In: ARKIVOC. - ISSN 1551-7012. - STAMPA. - V:(2004), pp. 286-300.
DESIGN, SYNTHESIS AND PRELIMINARY PHARMACOLOGICAL EVALUATION OF RIGID ANALOGUES OF THE NICOTINIC AGONIST 1,1-DIMETHYL-4-PHENYLPIPERAZINIUM IODIDE (DMPP)
GUANDALINI, LUCA;MARTINI, ELISABETTA;GUALTIERI, FULVIO;ROMANELLI, MARIA NOVELLA
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2004
Abstract
Some frozen analogues of 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP) and of 1-(3-pyridyl)piperazine have been synthesized and tested on rat cerebral cortex by means of binding studies. Among the synthesized substances, only compound 2c was found to displace [3H]-cytisine from the nicotinic binding sites on rat cerebral cortex. Some possible explanations for the inactivity of the other compounds are given
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