Rett syndrome (RTT) is a neurological disorder mainly caused by mutations in MeCP2 gene. It has been shown that MeCP2 impairments can lead to cytokine dysregulation due to MeCP2 regulatory role in T-helper and T-reg mediated responses, thus contributing to the pro-inflammatory status associated with RTT. Furthermore, RTT subjects suffer from an intestinal dysbiosis characterized by an abnormal expansion of the Candida population, a known factor responsible for the hyper-activation of pro-inflammatory immune responses. Therefore, we asked whether the intestinal fungal population of RTT subjects might contribute the sub-inflammatory status triggered by MeCP2 deficiency.
Intestinal Candida parapsilosis isolates from Rett syndrome subjects bear potential virulent traits and capacity to persist within the host / Strati, Francesco; Calabrò, Antonio; Donati, Claudio; De Felice, Claudio; Hayek, Joussef; Jousson, Olivier; Leoncini, Silvia; Renzi, Daniela; Rizzetto, Lisa; De Filippo, Carlotta; Cavalieri, Duccio. - In: BMC GASTROENTEROLOGY. - ISSN 1471-230X. - STAMPA. - 18:(2018), pp. 57-57. [10.1186/s12876-018-0785-z]
Intestinal Candida parapsilosis isolates from Rett syndrome subjects bear potential virulent traits and capacity to persist within the host
Calabrò, Antonio;Renzi, Daniela;Rizzetto, Lisa;De Filippo, Carlotta;Cavalieri, Duccio
2018
Abstract
Rett syndrome (RTT) is a neurological disorder mainly caused by mutations in MeCP2 gene. It has been shown that MeCP2 impairments can lead to cytokine dysregulation due to MeCP2 regulatory role in T-helper and T-reg mediated responses, thus contributing to the pro-inflammatory status associated with RTT. Furthermore, RTT subjects suffer from an intestinal dysbiosis characterized by an abnormal expansion of the Candida population, a known factor responsible for the hyper-activation of pro-inflammatory immune responses. Therefore, we asked whether the intestinal fungal population of RTT subjects might contribute the sub-inflammatory status triggered by MeCP2 deficiency.File | Dimensione | Formato | |
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