Convective therapies with high cut-off membranes (HCO) are usually not recommended because of theoretical excessive albumin loss. The aim of this in vitro study is to demonstrate the noninferior safety of pre-dilution hemodiafiltration with HCO (HCO-CVVHDF) with isotonic citrate anticoagulation (18 mmol/L) with respect to heparin anticoagulated hemodialysis with HCO (HCO-CVVHD) in terms of albumin removal and citrate load.
Albumin Loss and Citrate Load in Pre-Dilution High Cut-Off-CVVHDF with Regional Citrate (18 mmol/L) and High Cut-Off CVVHD with Systemic Heparin: An in vitro Study / Villa, G., Neri, M., De Rosa, S., Samoni, S., Chelazzi, C., Romagnoli, S., Lorenzin, A., de Cal, M., Ronco, C., De Gaudio, A.R.. - In: BLOOD PURIFICATION. - ISSN 0253-5068. - ELETTRONICO. - 46:(2018), pp. 205-213-213. [10.1159/000490342]
Albumin Loss and Citrate Load in Pre-Dilution High Cut-Off-CVVHDF with Regional Citrate (18 mmol/L) and High Cut-Off CVVHD with Systemic Heparin: An in vitro Study
Villa, Gianluca
;Chelazzi, Cosimo;Romagnoli, Stefano;De Gaudio, Angelo Raffaele
2018
Abstract
Convective therapies with high cut-off membranes (HCO) are usually not recommended because of theoretical excessive albumin loss. The aim of this in vitro study is to demonstrate the noninferior safety of pre-dilution hemodiafiltration with HCO (HCO-CVVHDF) with isotonic citrate anticoagulation (18 mmol/L) with respect to heparin anticoagulated hemodialysis with HCO (HCO-CVVHD) in terms of albumin removal and citrate load.
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