In the liver, adiponectin regulates both glucose and lipid metabolism and exerts an insulin-sensitizing effect. The binding of adiponectin with its specific receptors induces the activation of a proper signaling cascade that becomes altered in liver pathologies. This review describes the different signaling pathways in healthy and diseased hepatocytes, also highlighting the beneficial role of adiponectin in autophagy activation and hepatic regeneration.
Adiponectin Signaling Pathways in Liver Diseases / Gamberi, Tania; Magherini, Francesca; Modesti, Alessandra; Fiaschi, Tania. - In: BIOMEDICINES. - ISSN 2227-9059. - ELETTRONICO. - 6:(2018), pp. 52-52. [10.3390/biomedicines6020052]
Adiponectin Signaling Pathways in Liver Diseases
Gamberi, Tania;Magherini, Francesca;Modesti, Alessandra;Fiaschi, Tania
2018
Abstract
In the liver, adiponectin regulates both glucose and lipid metabolism and exerts an insulin-sensitizing effect. The binding of adiponectin with its specific receptors induces the activation of a proper signaling cascade that becomes altered in liver pathologies. This review describes the different signaling pathways in healthy and diseased hepatocytes, also highlighting the beneficial role of adiponectin in autophagy activation and hepatic regeneration.
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Descrizione: Adiponectin Signaling Pathways in Liver Diseases
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