Breast cancer (BC) is a heterogeneous disease which has been characterised and stratified by many platforms such as clinicopathological risk factors, genomic assays, computer generated models, and various "-omic" technologies. Genomic, proteomic and transcriptomic analysis in breast cancer research is well established, and metabolomics, which can be considered a downstream manifestation of the former disciplines, is of growing interest. The past decade has seen significant progress made within the field of clinical metabolomic BC research, with several groups demonstrating results with significant promise in the setting of BC screening and biological characterisation, as well as future potential for prognostic metabolomic biomarkers.
Metabolomics in breast cancer: A decade in review / McCartney, Amelia; Vignoli, Alessia; Biganzoli, Laura; Love, Richard; Tenori, Leonardo; Luchinat, Claudio; Di Leo, Angelo*. - In: CANCER TREATMENT REVIEWS. - ISSN 0305-7372. - STAMPA. - 67:(2018), pp. 88-96. [10.1016/j.ctrv.2018.04.012]
Metabolomics in breast cancer: A decade in review
Vignoli, Alessia;Tenori, Leonardo;Luchinat, Claudio;
2018
Abstract
Breast cancer (BC) is a heterogeneous disease which has been characterised and stratified by many platforms such as clinicopathological risk factors, genomic assays, computer generated models, and various "-omic" technologies. Genomic, proteomic and transcriptomic analysis in breast cancer research is well established, and metabolomics, which can be considered a downstream manifestation of the former disciplines, is of growing interest. The past decade has seen significant progress made within the field of clinical metabolomic BC research, with several groups demonstrating results with significant promise in the setting of BC screening and biological characterisation, as well as future potential for prognostic metabolomic biomarkers.
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