The results of this pilot study provide the first evidence that the hERG1 protein is expressed in primary BC, and its expression associates with molecular subtype. hERG1 apparently behaves as a protective factor, since it contributes to identify a subset of patients with better outcome. Overall, these data suggest that hERG1 might be an additional tool for the management of BC, nevertheless further investigations are warranted to better clarify hERG1 role and clinical usefulness in BC.
hERG1 channel expression associates with molecular subtypes and prognosis in breast cancer / Jessica Iorio, Icro Meattini, Simonetta Bianchi, Marco Bernini, Virginia Maragna, Luca Dominici,Donato Casella, Vania Vezzosi, Lorenzo Orzalesi, Jacopo Nori, Lorenzo Livi, Annarosa Arcangeli, Elena Lastraioli. - In: CANCER CELL INTERNATIONAL. - ISSN 1475-2867. - ELETTRONICO. - 18:(2018), pp. 93-100. [10.1186/s12935-018-0592-1]
hERG1 channel expression associates with molecular subtypes and prognosis in breast cancer.
Jessica Iorio;Icro Meattini;Simonetta Bianchi;Marco Bernini;MARAGNA, VIRGINIA;DOMINICI, LUCA;Donato Casella;Vania Vezzosi;Lorenzo Orzalesi;Lorenzo Livi;Annarosa Arcangeli;Elena Lastraioli
2018
Abstract
The results of this pilot study provide the first evidence that the hERG1 protein is expressed in primary BC, and its expression associates with molecular subtype. hERG1 apparently behaves as a protective factor, since it contributes to identify a subset of patients with better outcome. Overall, these data suggest that hERG1 might be an additional tool for the management of BC, nevertheless further investigations are warranted to better clarify hERG1 role and clinical usefulness in BC.
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