We measured receptor density and function in single μ, δ and μ /δ receptor double expression systems. GTPγ35 S binding, cAMP formation and arrestin recruitment were measured. Antinociceptive activity was measured in vivo using tail withdrawal and paw pressure tests following acute and chronic treatment. In some experiments, we collected tissues to measure receptor densities.
In vitro and in vivo characterization of the bifunctional u and o opioid receptor ligand UFP-505 / Dietis N; Niwa H; Tose R; McDonald J; Ruggieri V; Filaferro M; Vitale G; Micheli L;Ghelardini C;Salvadori S; Calo G; Guerrini R; Rowbotham DJ; Lambert DG. - In: BRITISH JOURNAL OF PHARMACOLOGY. - ISSN 1476-5381. - STAMPA. - (2018), pp. 2881-2896. [10.1111/bph.14199]
In vitro and in vivo characterization of the bifunctional u and o opioid receptor ligand UFP-505
Micheli L;Ghelardini C;Guerrini R;
2018
Abstract
We measured receptor density and function in single μ, δ and μ /δ receptor double expression systems. GTPγ35 S binding, cAMP formation and arrestin recruitment were measured. Antinociceptive activity was measured in vivo using tail withdrawal and paw pressure tests following acute and chronic treatment. In some experiments, we collected tissues to measure receptor densities.
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In vitro and in vivo characterization of the bifunctional μ and δ opioid receptor ligand UFP-505.pdf
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