Neuropeptide S (NPS) is an endogenous neuropeptide controlling anxiolysis, wakefulness, and analgesia. NPS containing neurons exist near to the locus coeruleus (LC) involved in the descending anti-nociceptive system. NPS interacts with central noradrenergic neurons; thus brain noradrenergic signaling may be involved in NPS-induced analgesia. We tested NPS analgesia in noradrenergic neuron-lesioned rats using a selective LC noradrenergic neurotoxin, N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4).
Central noradrenergic activity affects analgesic effect of Neuropeptide S / Jinushi K;Kushikata T;Kudo T;Calo G;Guerrini R; Hirota K. - In: JOURNAL OF ANESTHESIA. - ISSN 0913-8668. - ELETTRONICO. - (2018), pp. 0-0. [10.1007/s00540-017-2427-y]
Central noradrenergic activity affects analgesic effect of Neuropeptide S
Guerrini R;
2018
Abstract
Neuropeptide S (NPS) is an endogenous neuropeptide controlling anxiolysis, wakefulness, and analgesia. NPS containing neurons exist near to the locus coeruleus (LC) involved in the descending anti-nociceptive system. NPS interacts with central noradrenergic neurons; thus brain noradrenergic signaling may be involved in NPS-induced analgesia. We tested NPS analgesia in noradrenergic neuron-lesioned rats using a selective LC noradrenergic neurotoxin, N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4).
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