BACKGROUND: The CHA2DS2-VASc score predicts stroke in patients with atrial fibrillation and has been reported to have a prognostic role even in acute coronary syndrome patients. The Takotsubo syndrome is a condition that mimics acute coronary syndrome and may present several complications including stroke. We sought to assess the ability of CHA2DS2-VASc score to predict adverse events in Takotsubo syndrome patients. METHODS AND RESULTS: Overall, 371 Takotsubo syndrome patients were enrolled in a prospective registry. Patients were divided into 3 groups according to the CHA2DS2-VASc score: Group A (≤1), B (2-3), and C (≥4). The median CHA2DS2-VASc score was 3 (interquartile range: 2-4). Overall, 9%, 42%, and 49% were included in Group A, B, and C, respectively. Follow-up length was 26±20 months. The mortality rate was 6%, 7%, and 17% in Group A, B, and C, respectively (P=0.011). The stroke rate was 3% and not different among the 3 groups. Estimated major adverse cardiac and cerebrovascular events (the composite of death, myocardial infarction, and stroke) rates in the 3 groups were 6%, 9%, and 17% in Group A, B, and C, respectively (P=0.033). The CHA2DS2-VASc score resulted as a predictor of major adverse cardiac and cerebrovascular events (odds ratio 2.1, 95% confidence interval, 1.2-3.6; P=0.01) and all-cause mortality (odds ratio 1.5, 95% confidence interval, 1.2-1.9; P=0.001). CONCLUSIONS: In Takotsubo syndrome, the CHA2DS2-VASc score allows prediction of cardiovascular events and mortality at long-term follow-up.

Risk stratification using the CHA2DS2-VASc score in Takotsubo syndrome: Data from the Takotsubo Italian network / Parodi, Guido; Scudiero, Fernando; Citro, Rodolfo; Silverio, Angelo; Bellandi, Benedetta; Zito, Concetta; Antonini-Canterin, Francesco; Rigo, Fausto; Zocchi, Chiara; Bossone, Eduardo; Salerno-Uriarte, Jorge; Piscione, Federico; Di Mario, Carlo; Armentano, Corinna; Astarita, Costantino; Coppola, Antonino; Ravera, Amelia; Prota, Costantina; Bottiglieri, Pompea; Bovelli, Daniella; Patella, Marco Mariano; Costantino, Marco Fabio; Gregorio, Giovanni; Santoro, Michele; Manganelli, Fiore; Rotondi, Francesco; Del Pace, Stefano; Pascotto, Marco; Grolla, Elisabetta; Tagliamonte, Ercole; Bianchi, Alfredo; Marinosci, Giovanni; Pappalettera, Michele; Pozzi, Andrea; Nardi, Federico; Novo, Giuseppina; Bovenzi, Francesco. - In: JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE. - ISSN 2047-9980. - ELETTRONICO. - 6:(2017), pp. 1-6. [10.1161/JAHA.117.006065]

Risk stratification using the CHA2DS2-VASc score in Takotsubo syndrome: Data from the Takotsubo Italian network

Parodi, Guido;Scudiero, Fernando;Bellandi, Benedetta;Zocchi, Chiara;Di Mario, Carlo;Pozzi, Andrea;Nardi, Federico;
2017

Abstract

BACKGROUND: The CHA2DS2-VASc score predicts stroke in patients with atrial fibrillation and has been reported to have a prognostic role even in acute coronary syndrome patients. The Takotsubo syndrome is a condition that mimics acute coronary syndrome and may present several complications including stroke. We sought to assess the ability of CHA2DS2-VASc score to predict adverse events in Takotsubo syndrome patients. METHODS AND RESULTS: Overall, 371 Takotsubo syndrome patients were enrolled in a prospective registry. Patients were divided into 3 groups according to the CHA2DS2-VASc score: Group A (≤1), B (2-3), and C (≥4). The median CHA2DS2-VASc score was 3 (interquartile range: 2-4). Overall, 9%, 42%, and 49% were included in Group A, B, and C, respectively. Follow-up length was 26±20 months. The mortality rate was 6%, 7%, and 17% in Group A, B, and C, respectively (P=0.011). The stroke rate was 3% and not different among the 3 groups. Estimated major adverse cardiac and cerebrovascular events (the composite of death, myocardial infarction, and stroke) rates in the 3 groups were 6%, 9%, and 17% in Group A, B, and C, respectively (P=0.033). The CHA2DS2-VASc score resulted as a predictor of major adverse cardiac and cerebrovascular events (odds ratio 2.1, 95% confidence interval, 1.2-3.6; P=0.01) and all-cause mortality (odds ratio 1.5, 95% confidence interval, 1.2-1.9; P=0.001). CONCLUSIONS: In Takotsubo syndrome, the CHA2DS2-VASc score allows prediction of cardiovascular events and mortality at long-term follow-up.
6
1
6
Parodi, Guido; Scudiero, Fernando; Citro, Rodolfo; Silverio, Angelo; Bellandi, Benedetta; Zito, Concetta; Antonini-Canterin, Francesco; Rigo, Fausto; Zocchi, Chiara; Bossone, Eduardo; Salerno-Uriarte, Jorge; Piscione, Federico; Di Mario, Carlo; Armentano, Corinna; Astarita, Costantino; Coppola, Antonino; Ravera, Amelia; Prota, Costantina; Bottiglieri, Pompea; Bovelli, Daniella; Patella, Marco Mariano; Costantino, Marco Fabio; Gregorio, Giovanni; Santoro, Michele; Manganelli, Fiore; Rotondi, Francesco; Del Pace, Stefano; Pascotto, Marco; Grolla, Elisabetta; Tagliamonte, Ercole; Bianchi, Alfredo; Marinosci, Giovanni; Pappalettera, Michele; Pozzi, Andrea; Nardi, Federico; Novo, Giuseppina; Bovenzi, Francesco
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2158/1135673
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 16
  • ???jsp.display-item.citation.isi??? 20
social impact