We propose that tumor cells are subjected to metabolic reprogramming after LMW-PTP silencing, enhancing glycolytic flux, probably to compensate the inhibition of mitochondrial metabolism. Our results highlight the involvement of LMW-PTP in regulating glucose metabolism in A375 melanoma cells.
LMW-PTP modulates glucose metabolism in cancer cells / Giulia Lori, Tania Gamberi, Paolo Paoli, Anna Caselli, Erica Pranzini, Riccardo Marzocchini, Alessandra Modesti, Giovanni Raugei. - In: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. - ISSN 0304-4165. - ELETTRONICO. - 1862:(2018), pp. 2533-2544. [10.1016/j.bbagen.2018.08.003]
LMW-PTP modulates glucose metabolism in cancer cells
LORI, GIULIAInvestigation
;Tania GamberiInvestigation
;Paolo PaoliInvestigation
;Anna CaselliInvestigation
;PRANZINI, ERICAInvestigation
;Riccardo MarzocchiniMembro del Collaboration Group
;Alessandra ModestiMembro del Collaboration Group
;Giovanni Raugei
Membro del Collaboration Group
2018
Abstract
We propose that tumor cells are subjected to metabolic reprogramming after LMW-PTP silencing, enhancing glycolytic flux, probably to compensate the inhibition of mitochondrial metabolism. Our results highlight the involvement of LMW-PTP in regulating glucose metabolism in A375 melanoma cells.
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