PURPOSE: The aim of the present prospective study was to evaluate the lacrimal fluid concentration of HMGB1 in young patients affected by Vernal Keratoconjunctivitis (VKC) compared to a control group of healthy subjects of same age. METHODS: Tear fluids was collected in a group of VKC patients and compared to a control group of healthy subjects. HMGB1 concentration was measured using the HMGB1 ELISA II test both in VCK and control subjects. RESULTS: The mean concentration of HMGB1 in tear fluids of 45 VKC patients was 0,977 ± 0,72 ng/ml whereas in the control group was 0,24 ± 0,25 ng/ml and the difference was statistically significant (p = 0,000106) Conclusion: The concentration of HMGB1 in VCK patients was found to be significantly increased, suggesting a possible role of this protein in the inflammatory mechanism of VKC.
Increased Lacrimal Fluid Level of HMGB1 in Vernal Keratoconjunctivitis / Caputo, Roberto; Pasti, Mattia*; de Libero, Cinzia; Mori, Francesca; Barni, Simona; Danti, Gioia; Buonvicino, Daniela; Urru, Matteo; Chiarugi, Alberto; Pucci, Neri. - In: OCULAR IMMUNOLOGY AND INFLAMMATION. - ISSN 0927-3948. - STAMPA. - (2018), pp. 1-5. [10.1080/09273948.2018.1467465]
Increased Lacrimal Fluid Level of HMGB1 in Vernal Keratoconjunctivitis
PASTI, MATTIA;Mori, Francesca;Barni, Simona;Buonvicino, Daniela;Urru, Matteo;Chiarugi, Alberto;Pucci, Neri
2018
Abstract
PURPOSE: The aim of the present prospective study was to evaluate the lacrimal fluid concentration of HMGB1 in young patients affected by Vernal Keratoconjunctivitis (VKC) compared to a control group of healthy subjects of same age. METHODS: Tear fluids was collected in a group of VKC patients and compared to a control group of healthy subjects. HMGB1 concentration was measured using the HMGB1 ELISA II test both in VCK and control subjects. RESULTS: The mean concentration of HMGB1 in tear fluids of 45 VKC patients was 0,977 ± 0,72 ng/ml whereas in the control group was 0,24 ± 0,25 ng/ml and the difference was statistically significant (p = 0,000106) Conclusion: The concentration of HMGB1 in VCK patients was found to be significantly increased, suggesting a possible role of this protein in the inflammatory mechanism of VKC.I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.