11β-Hydroxysteroid dehydrogenase 1 and 2 (11β-HSD1 and 11β-HSD2) are involved in the complex mechanism of human parturition. The present study examined mRNA expression and activity of membrane 11β-HSD1 and placental 11β-HSD2 in postdate pregnancies according to response of labor induction. In comparison to postdate women who had spontaneous delivery or after induction the non-responders showed significantly low c and high 11β-HSD2 expression and activity These data suggest that disrupted expression and activity of 11β-HSDs may occur in some postdate pregnancies.
Postdate pregnancy: Changes of placental/membranes 11β-hydroxysteroid dehydrogenase mRNA and activity / Novembri, R.; Voltolini, C.; Torricelli, M.; Severi, F.M.; Marcolongo, P.; Benedetti, A.; Challis, J.R.; Petraglia, F.*. - In: PLACENTA. - ISSN 0143-4004. - ELETTRONICO. - 34:(2013), pp. 1102-1104. [10.1016/j.placenta.2013.08.011]
Postdate pregnancy: Changes of placental/membranes 11β-hydroxysteroid dehydrogenase mRNA and activity
Petraglia, F.
2013
Abstract
11β-Hydroxysteroid dehydrogenase 1 and 2 (11β-HSD1 and 11β-HSD2) are involved in the complex mechanism of human parturition. The present study examined mRNA expression and activity of membrane 11β-HSD1 and placental 11β-HSD2 in postdate pregnancies according to response of labor induction. In comparison to postdate women who had spontaneous delivery or after induction the non-responders showed significantly low c and high 11β-HSD2 expression and activity These data suggest that disrupted expression and activity of 11β-HSDs may occur in some postdate pregnancies.
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