Human leucocyte antigen-G (HLA-G) is a non-classical HLA class I molecule with an important role at the fetus-maternal interface, preventing fetus recognition and abortion. The role of HLA-G as an immune-modulatory and anti-inflammatory molecule has led to investigate its role in pathological conditions. In these years, HLA-G has been shown to have an important implication in inflammatory pathologies. The focus of this review is to up-date the scientific knowledge on the expression of HLA-G molecules in inflammatory conditions.
New insights into HLA-G and inflammatory diseases / Rizzo, Roberta*; Bortolotti, Daria; Baricordi, Olavio R.; Fainardi, Enrico. - In: INFLAMMATION & ALLERGY - DRUG TARGETS. - ISSN 1871-5281. - ELETTRONICO. - 11:(2012), pp. 448-463. [10.2174/187152812803590037]
New insights into HLA-G and inflammatory diseases
Fainardi, Enrico
2012
Abstract
Human leucocyte antigen-G (HLA-G) is a non-classical HLA class I molecule with an important role at the fetus-maternal interface, preventing fetus recognition and abortion. The role of HLA-G as an immune-modulatory and anti-inflammatory molecule has led to investigate its role in pathological conditions. In these years, HLA-G has been shown to have an important implication in inflammatory pathologies. The focus of this review is to up-date the scientific knowledge on the expression of HLA-G molecules in inflammatory conditions.
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