We designed a large multicentric study to analyse the presence of MSRV particles in blood and CSF of a large cohort of patients and controls from different European areas. 149 MS patients and 153 neurological and healthy controls were selected from Sardinia, Spain, Northern-Italy and Sweden. To avoid biological and inter-assay variability MSRV was detected within a single laboratory through nested and real-time PCR assays specific for pol and env genes. MSRV detection in blood and CSF of MS patients and controls in populations of different ethnicity gave significant differences (p<0.05 compared to neurological controls and <0.001 compared to healthy controls). The presence and viral load of MSRV are significantly associated with MS as compared to neurological and healthy controls in all ethnic groups.
Multiple Sclerosis and HERV-W/MSRV: A Multicentric Study / Arru, Giannina; Mameli, Giuseppe; Astone, Vito; Serra, Caterina; Huang, Yu-Min; Link, Hans; Fainardi, Enrico; Castellazzi, Massimiliano; Granieri, Enrico; Fernandez, Miriam; Villoslada, Pablo; Fois, Maria Laura; Sanna, Alessandra; Rosati, Giulio; Dolei, Antonina; Sotgiu, Stefano. - In: INTERNATIONAL JOURNAL OF BIOMEDICAL SCIENCE. - ISSN 1550-9702. - ELETTRONICO. - 3:(2007), pp. 292-297.
Multiple Sclerosis and HERV-W/MSRV: A Multicentric Study
Fainardi, Enrico;
2007
Abstract
We designed a large multicentric study to analyse the presence of MSRV particles in blood and CSF of a large cohort of patients and controls from different European areas. 149 MS patients and 153 neurological and healthy controls were selected from Sardinia, Spain, Northern-Italy and Sweden. To avoid biological and inter-assay variability MSRV was detected within a single laboratory through nested and real-time PCR assays specific for pol and env genes. MSRV detection in blood and CSF of MS patients and controls in populations of different ethnicity gave significant differences (p<0.05 compared to neurological controls and <0.001 compared to healthy controls). The presence and viral load of MSRV are significantly associated with MS as compared to neurological and healthy controls in all ethnic groups.File | Dimensione | Formato | |
---|---|---|---|
IJBS 2007.pdf
Accesso chiuso
Tipologia:
Pdf editoriale (Version of record)
Licenza:
Tutti i diritti riservati
Dimensione
467.28 kB
Formato
Adobe PDF
|
467.28 kB | Adobe PDF | Richiedi una copia |
I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.