GM3-ganglioside is known to be involved in melanoma proliferation. In order to modulate metastatic related events, we have functionalized multi-walled carbon nanotubes (MWCNTs) with multiple copies of a GM3-lactone mimetic. The MWCNTs proved to guarantee the appropriate spatial arrangement of the mimetic allowing a stronger inhibition of migration and invasiveness of human melanoma (A375) cells compared to other multivalent constructs reported before. In addition, the effect of the multivalent tubular conjugate on the inhibition of specific tyrosine kinases, which are associated with the ganglioside complexes within the membrane domains, was demonstrated. Finally, the short-term fate of the conjugate was assessed, for the first time, by means of the 1H NMR relaxometry technique by exploiting the signal arising from the CNTs.

Conjugation of a GM3 lactone mimetic on carbon nanotubes enhances the related inhibition of melanoma-associated metastatic events / Arosio, Paolo; Comito, Giuseppina; Orsini, Francesco; Lascialfari, Alessandro; Chiarugi, Paola; Ménard-Moyon, Cécilia*; Nativi, Cristina; Richichi, Barbara. - In: ORGANIC & BIOMOLECULAR CHEMISTRY. - ISSN 1477-0520. - ELETTRONICO. - 16:(2018), pp. 6086-6095. [10.1039/c8ob01817k]

Conjugation of a GM3 lactone mimetic on carbon nanotubes enhances the related inhibition of melanoma-associated metastatic events

Comito, Giuseppina
Membro del Collaboration Group
;
LASCIALFARI, ALESSANDRO
Membro del Collaboration Group
;
Chiarugi, Paola
Membro del Collaboration Group
;
Nativi, Cristina
Membro del Collaboration Group
;
Richichi, Barbara
2018

Abstract

GM3-ganglioside is known to be involved in melanoma proliferation. In order to modulate metastatic related events, we have functionalized multi-walled carbon nanotubes (MWCNTs) with multiple copies of a GM3-lactone mimetic. The MWCNTs proved to guarantee the appropriate spatial arrangement of the mimetic allowing a stronger inhibition of migration and invasiveness of human melanoma (A375) cells compared to other multivalent constructs reported before. In addition, the effect of the multivalent tubular conjugate on the inhibition of specific tyrosine kinases, which are associated with the ganglioside complexes within the membrane domains, was demonstrated. Finally, the short-term fate of the conjugate was assessed, for the first time, by means of the 1H NMR relaxometry technique by exploiting the signal arising from the CNTs.
2018
16
6086
6095
Arosio, Paolo; Comito, Giuseppina; Orsini, Francesco; Lascialfari, Alessandro; Chiarugi, Paola; Ménard-Moyon, Cécilia*; Nativi, Cristina; Richichi, Barbara
File in questo prodotto:
File Dimensione Formato  
OBC 2018.pdf

Accesso chiuso

Descrizione: PDF Editoriale
Tipologia: Pdf editoriale (Version of record)
Licenza: Creative commons
Dimensione 1.44 MB
Formato Adobe PDF
1.44 MB Adobe PDF   Richiedi una copia

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1142143
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 9
  • ???jsp.display-item.citation.isi??? 8
social impact