The practical synthesis of novel multivalent fluorescent quantum-dot-based probes to target cellular matrix metalloproteinases (MMPs) (MT-MMPs) is reported. We show that these probes, which are decorated with a nanomolar water-soluble MMP inhibitor, can be used to label preferentially the surface of cancer cells that are known to express MMPs while no binding was observed on cells that do not.
Quantum Dot-Based Probes for Labeling and Imaging of Cells that Express Matrix Metalloproteinases / Benito-Alifonso, David; Richichi, Barbara; Baldoneschi, Veronica; Berry, Monica; Fragai, Marco; Salerno, Gianluca; Galan, M. Carmen*; Nativi, Cristina. - In: ACS OMEGA. - ISSN 2470-1343. - ELETTRONICO. - 3:(2018), pp. 9822-9826. [10.1021/acsomega.8b00633]
Quantum Dot-Based Probes for Labeling and Imaging of Cells that Express Matrix Metalloproteinases
Richichi, Barbara;Baldoneschi, Veronica;Fragai, Marco;Salerno, Gianluca;Nativi, Cristina
2018
Abstract
The practical synthesis of novel multivalent fluorescent quantum-dot-based probes to target cellular matrix metalloproteinases (MMPs) (MT-MMPs) is reported. We show that these probes, which are decorated with a nanomolar water-soluble MMP inhibitor, can be used to label preferentially the surface of cancer cells that are known to express MMPs while no binding was observed on cells that do not.
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