The practical synthesis of novel multivalent fluorescent quantum-dot-based probes to target cellular matrix metalloproteinases (MMPs) (MT-MMPs) is reported. We show that these probes, which are decorated with a nanomolar water-soluble MMP inhibitor, can be used to label preferentially the surface of cancer cells that are known to express MMPs while no binding was observed on cells that do not.

Quantum Dot-Based Probes for Labeling and Imaging of Cells that Express Matrix Metalloproteinases / Benito-Alifonso, David; Richichi, Barbara; Baldoneschi, Veronica; Berry, Monica; Fragai, Marco; Salerno, Gianluca; Galan, M. Carmen*; Nativi, Cristina. - In: ACS OMEGA. - ISSN 2470-1343. - ELETTRONICO. - 3:(2018), pp. 9822-9826. [10.1021/acsomega.8b00633]

Quantum Dot-Based Probes for Labeling and Imaging of Cells that Express Matrix Metalloproteinases

Richichi, Barbara;Baldoneschi, Veronica;Fragai, Marco;Salerno, Gianluca;Nativi, Cristina
2018

Abstract

The practical synthesis of novel multivalent fluorescent quantum-dot-based probes to target cellular matrix metalloproteinases (MMPs) (MT-MMPs) is reported. We show that these probes, which are decorated with a nanomolar water-soluble MMP inhibitor, can be used to label preferentially the surface of cancer cells that are known to express MMPs while no binding was observed on cells that do not.
2018
3
9822
9826
Benito-Alifonso, David; Richichi, Barbara; Baldoneschi, Veronica; Berry, Monica; Fragai, Marco; Salerno, Gianluca; Galan, M. Carmen*; Nativi, Cristina...espandi
File in questo prodotto:
File Dimensione Formato  
ACSOmega2018.pdf

Accesso chiuso

Descrizione: PDF editoriale
Tipologia: Pdf editoriale (Version of record)
Licenza: Creative commons
Dimensione 1.91 MB
Formato Adobe PDF
1.91 MB Adobe PDF   Richiedi una copia

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1142145
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 4
social impact