The presence of lactate in human tumours has been long neglected, confined to the role of a waste product derived from glycolysis and as a biomarker of malignancy. More recently, lactate has been rediscovered as signalling molecule that plays important roles in the regulation of the metabolic pathways, the immune response, and cell-to-cell communication within the tumour microenvironment. This review examines recent discoveries about the functional role of lactate in shaping the behaviour and the phenotype of tumour and tumour-associated cells, and describes potential clinical approaches to target lactate transport and metabolism in tumours.

Lactate: A Metabolic Driver in the Tumour Landscape / Ippolito, Luigi; Morandi, Andrea; Giannoni, Elisa; Chiarugi, Paola. - In: TRENDS IN BIOCHEMICAL SCIENCES. - ISSN 0968-0004. - ELETTRONICO. - (2018), pp. 153-166. [10.1016/j.tibs.2018.10.011]

Lactate: A Metabolic Driver in the Tumour Landscape

Ippolito, Luigi;Morandi, Andrea;Giannoni, Elisa
Membro del Collaboration Group
;
Chiarugi, Paola
2018

Abstract

The presence of lactate in human tumours has been long neglected, confined to the role of a waste product derived from glycolysis and as a biomarker of malignancy. More recently, lactate has been rediscovered as signalling molecule that plays important roles in the regulation of the metabolic pathways, the immune response, and cell-to-cell communication within the tumour microenvironment. This review examines recent discoveries about the functional role of lactate in shaping the behaviour and the phenotype of tumour and tumour-associated cells, and describes potential clinical approaches to target lactate transport and metabolism in tumours.
2018
153
166
Ippolito, Luigi; Morandi, Andrea; Giannoni, Elisa; Chiarugi, Paola
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1148018
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