l-2-Hydroxy acid oxidases are flavin mononucleotide-dependent peroxisomal enzymes, responsible for the oxidation of l-2-hydroxy acids to ketoacids, resulting in the formation of hydrogen peroxide. We investigated the role of HAO2, a member of this family, in rat, mouse and human hepatocarcinogenesis.
The metabolic gene HAO2 is downregulated in hepatocellular carcinoma and predicts metastasis and poor survival / Mattu, S., Fornari, F., Quagliata, L., Perra, A., Angioni, M.M., Petrelli, A., Menegon, S., Morandi, A., Chiarugi, P., Ledda-Columbano, G.M., Gramantieri, L., Terracciano, L., Giordano, S., Columbano, A.. - In: JOURNAL OF HEPATOLOGY. - ISSN 0168-8278. - ELETTRONICO. - 64:(2016), pp. 891-8-898. [10.1016/j.jhep.2015.11.029]
The metabolic gene HAO2 is downregulated in hepatocellular carcinoma and predicts metastasis and poor survival
PERRA, ANDREA;Morandi, Andrea;Chiarugi, Paola;COLUMBANO, AMEDEO
2016
Abstract
l-2-Hydroxy acid oxidases are flavin mononucleotide-dependent peroxisomal enzymes, responsible for the oxidation of l-2-hydroxy acids to ketoacids, resulting in the formation of hydrogen peroxide. We investigated the role of HAO2, a member of this family, in rat, mouse and human hepatocarcinogenesis.
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