OBJECTIVE: To evaluate whether single nucleotide FSH receptor and DAZL gene polymorphisms are associated with menarche and menopause timing. DESIGN: Prospective study. SETTING: Siena and Münster Universities. PATIENT(S): Physiologically menopausal women. INTERVENTION(S): The presence of FSH receptor or DAZL gene polymorphisms was investigated. Blood samples were collected and polymorphisms evaluated in extracted genomic DNA. MAIN OUTCOME MEASURE(S): Menarche age, menopausal age, and total years of fertility were evaluated on the basis of FSH receptor (genotypes Asn/Asn, Asn/Ser, and Ser/Ser at codon 680) and DAZL gene. RESULT(S): The median age of menarche was 13 years in the Asn/Asn group and 12 years in the Asn/Ser and Ser/Ser groups. The median age at menopause was 50 years in the Asn/Asn and Asn/Ser groups and 51 years in the Ser/Ser group. The length of the fertile period was 37 years in the Asn/Asn group, 38 years in the Asn/Ser group, and 39 years in the Ser/Ser group. Regarding the DAZL polymorphism, A/A, A/G, and G/G had the same age at menarche, age at menopause, and length of fertile period. CONCLUSION(S): We found that genotype of FSH receptor or SNP of DAZL do not predict the age at natural menopause and duration of fertility in women. The presence of Asn680/Asn680 genotype is associated with a slightly delayed age at menarche.
Follicle-stimulating hormone receptor and DAZL gene polymorphisms do not affect the age of menopause / Zerbetto, Irene; Gromoll, Jörg; Luisi, Stefano; Reis, Fernando M.; Nieschlag, Eberhard; Simoni, Manuela; Petraglia, Felice*. - In: FERTILITY AND STERILITY. - ISSN 0015-0282. - ELETTRONICO. - 90:(2008), pp. 2264-2268. [10.1016/j.fertnstert.2007.10.036]
Follicle-stimulating hormone receptor and DAZL gene polymorphisms do not affect the age of menopause
Petraglia, Felice
2008
Abstract
OBJECTIVE: To evaluate whether single nucleotide FSH receptor and DAZL gene polymorphisms are associated with menarche and menopause timing. DESIGN: Prospective study. SETTING: Siena and Münster Universities. PATIENT(S): Physiologically menopausal women. INTERVENTION(S): The presence of FSH receptor or DAZL gene polymorphisms was investigated. Blood samples were collected and polymorphisms evaluated in extracted genomic DNA. MAIN OUTCOME MEASURE(S): Menarche age, menopausal age, and total years of fertility were evaluated on the basis of FSH receptor (genotypes Asn/Asn, Asn/Ser, and Ser/Ser at codon 680) and DAZL gene. RESULT(S): The median age of menarche was 13 years in the Asn/Asn group and 12 years in the Asn/Ser and Ser/Ser groups. The median age at menopause was 50 years in the Asn/Asn and Asn/Ser groups and 51 years in the Ser/Ser group. The length of the fertile period was 37 years in the Asn/Asn group, 38 years in the Asn/Ser group, and 39 years in the Ser/Ser group. Regarding the DAZL polymorphism, A/A, A/G, and G/G had the same age at menarche, age at menopause, and length of fertile period. CONCLUSION(S): We found that genotype of FSH receptor or SNP of DAZL do not predict the age at natural menopause and duration of fertility in women. The presence of Asn680/Asn680 genotype is associated with a slightly delayed age at menarche.
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