A standardization of minor salivary gland (MSG) histopathology in primary Sjögren's syndrome (pSS) has been recently proposed. Although there is strong agreement that germinal center (GC)-like structures should be routinely identified, due to their prognostic value, a consensus regarding the best protocol is still lacking. Aim of this study was to compare the performance of different histological techniques and operators to identify GC-like structures in pSS MSGs. MSG biopsies from 50 pSS patients were studied.
Different operators and histologic techniques in the assessment of germinal center-like structures in primary Sjögren's syndrome minor salivary glands / Carubbi, Francesco; Alunno, Alessia; Cipriani, Paola; Coletti, Gino; Bigerna, Barbara; Manetti, Mirko; Di Benedetto, Paola; Bistoni, Onelia; Cipolloni, Gianluca; Liakouli, Vasiliki; Ruscitti, Piero; Bartoloni, Elena; Giacomelli, Roberto; Gerli, Roberto. - In: PLOS ONE. - ISSN 1932-6203. - ELETTRONICO. - 14:(2019), pp. e0211142-e0211142. [10.1371/journal.pone.0211142]
Different operators and histologic techniques in the assessment of germinal center-like structures in primary Sjögren's syndrome minor salivary glands
Manetti, Mirko;
2019
Abstract
A standardization of minor salivary gland (MSG) histopathology in primary Sjögren's syndrome (pSS) has been recently proposed. Although there is strong agreement that germinal center (GC)-like structures should be routinely identified, due to their prognostic value, a consensus regarding the best protocol is still lacking. Aim of this study was to compare the performance of different histological techniques and operators to identify GC-like structures in pSS MSGs. MSG biopsies from 50 pSS patients were studied.
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