Cerebral fat embolism (CFE) is an uncommon incomplete type of fat embolism syndrome (FES), characterized by purely cerebral involvement. It usually occurs 12-72 hours after the initial trigger, mainly represented by closed, long-bone multiple fractures of the lower extremities. Neurological manifestations are mainly characterized by headache, confusion, seizures, focal deficit, and alteration of the consciousness state up to coma onset. It represents a diagnostic challenge, above all when secondary to uncommon nontraumatic causes, because neurological signs and symptoms are variable and nonspecific, not satisfying the Gurd and Wilson's criteria, the diagnostic features most widely used today for FES diagnosis. Neuroimaging (mainly MRI, but in some cases, brain computed tomography too) can hasten the diagnosis, avoiding other unnecessary investigations and treatment. Usually self-limiting, CFE may sometimes be fatal. Treatment is to date mainly supportive and prophylactic strategies are considered an important tool to decrease the development of fat embolism and, consequently, the rate of CFE.

From the diagnosis to the therapeutic management: cerebral fat embolism, a clinical challenge / Scarpino, Maenia; Lanzo, Giovanni; Lolli, Francesco; Grippo, Antonello. - In: INTERNATIONAL JOURNAL OF GENERAL MEDICINE. - ISSN 1178-7074. - STAMPA. - Volume 12:(2019), pp. 39-48. [10.2147/IJGM.S177407]

From the diagnosis to the therapeutic management: cerebral fat embolism, a clinical challenge

Lanzo, Giovanni;Lolli, Francesco;Grippo, Antonello
2019

Abstract

Cerebral fat embolism (CFE) is an uncommon incomplete type of fat embolism syndrome (FES), characterized by purely cerebral involvement. It usually occurs 12-72 hours after the initial trigger, mainly represented by closed, long-bone multiple fractures of the lower extremities. Neurological manifestations are mainly characterized by headache, confusion, seizures, focal deficit, and alteration of the consciousness state up to coma onset. It represents a diagnostic challenge, above all when secondary to uncommon nontraumatic causes, because neurological signs and symptoms are variable and nonspecific, not satisfying the Gurd and Wilson's criteria, the diagnostic features most widely used today for FES diagnosis. Neuroimaging (mainly MRI, but in some cases, brain computed tomography too) can hasten the diagnosis, avoiding other unnecessary investigations and treatment. Usually self-limiting, CFE may sometimes be fatal. Treatment is to date mainly supportive and prophylactic strategies are considered an important tool to decrease the development of fat embolism and, consequently, the rate of CFE.
2019
Volume 12
39
48
Goal 3: Good health and well-being for people
Scarpino, Maenia; Lanzo, Giovanni; Lolli, Francesco; Grippo, Antonello
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1149117
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