Multidefence antioxidants represent a valuable solution for the protection against oxidative stress. From the planned synthesis of a catechol-tocopherol hybrid, we isolated a catechol-hydroquinone hybrid through a BBr3-mediated benzochromene-fluoren-1-ol transposition. The compound prepared showed a remarkable chain-breaking antioxidant in the catechol portion, while the very sensitive hydroquinone moiety revealed to be an efficient generator of hydroperoxyl radicals
From catechol-tocopherol to catechol-hydroquinone polyphenolic antioxidant hybrids / Viglianisi, Caterina; Menichetti, Stefano*; Morelli, Paola; Baschieri, Andrea; Amorati, Riccardo. - In: HETEROATOM CHEMISTRY. - ISSN 1042-7163. - STAMPA. - 29:(2018), pp. e21466-e21466. [10.1002/hc.21466]
From catechol-tocopherol to catechol-hydroquinone polyphenolic antioxidant hybrids
Viglianisi, Caterina;Menichetti, Stefano
;
2018
Abstract
Multidefence antioxidants represent a valuable solution for the protection against oxidative stress. From the planned synthesis of a catechol-tocopherol hybrid, we isolated a catechol-hydroquinone hybrid through a BBr3-mediated benzochromene-fluoren-1-ol transposition. The compound prepared showed a remarkable chain-breaking antioxidant in the catechol portion, while the very sensitive hydroquinone moiety revealed to be an efficient generator of hydroperoxyl radicals
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