Background. 99mTc-HMDP scintigraphy has proved its efficacy in non-invasive diagnosis of cardiac amyloidosis (CA) and is currently interpreted according to the Perugini qualitative assessment. Several semi-quantitative indices have been proposed to overcome inherent possible limitations of visual grading. Our aim was to comparatively evaluate six different indices and their diagnostic performance. Methods. We retrospectively reviewed scintigraphy of 76 patients (53 ATTR, 12 AL, 11 LVH) who underwent diagnostic evaluation at our centre. ROC-curve analysis was performed to identify optimal cut-off and relative diagnostic accuracy of six different indices (of which one was proposed for the first time), both in identifying CA patients and in discriminating patients according to their Perugini score. Results. Heart/Whole-body ratios proved to be the most accurate (100%) in identifying CA patients. Heart/Pelvis ratio (with soft tissue background correction) offered acceptable accuracy (98%), with the largest area under the curve (AUC) (0.98) in discriminating patients with Perugini ‡ 2. Heart/Contralateral Lung ratio confirmed to be exposed to confounding background noise in case of simultaneous lung uptake. Heart/Skull ratio had the worst performance, with six false-negative patients in ATTR identification. Conclusion. Heart/Whole-body ratios may be robust and effective semi-quantitative indices for the evaluation of CA by means of scintigraphy

Semi-quantitative indices of cardiac uptake in patients with suspected cardiac amyloidosis undergoing 99mTc-HMDP scintigraphy / Gallini, Chiara; Tutino, Francesca; Martone, Raffaele; Ciaccio, Alfonso; Costanzo, Egidio Natalino; Taborchi, Giulia; Morini, Sofia; Bartolini, Simone; Farsetti, Silvia; Di Mario, Carlo; Perfetto, Federico; Cappelli, Francesco. - In: JOURNAL OF NUCLEAR CARDIOLOGY. - ISSN 1071-3581. - STAMPA. - 14:(2021), pp. 0-0. [10.1007/s12350-019-01643-w]

Semi-quantitative indices of cardiac uptake in patients with suspected cardiac amyloidosis undergoing 99mTc-HMDP scintigraphy

Tutino, Francesca
Methodology
;
Martone, Raffaele
Data Curation
;
Ciaccio, Alfonso
Data Curation
;
Taborchi, Giulia
Data Curation
;
Morini, Sofia
Data Curation
;
Bartolini, Simone
Data Curation
;
Farsetti, Silvia
Methodology
;
Di Mario, Carlo
Methodology
;
Perfetto, Federico
Conceptualization
;
Cappelli, Francesco
Conceptualization
2021

Abstract

Background. 99mTc-HMDP scintigraphy has proved its efficacy in non-invasive diagnosis of cardiac amyloidosis (CA) and is currently interpreted according to the Perugini qualitative assessment. Several semi-quantitative indices have been proposed to overcome inherent possible limitations of visual grading. Our aim was to comparatively evaluate six different indices and their diagnostic performance. Methods. We retrospectively reviewed scintigraphy of 76 patients (53 ATTR, 12 AL, 11 LVH) who underwent diagnostic evaluation at our centre. ROC-curve analysis was performed to identify optimal cut-off and relative diagnostic accuracy of six different indices (of which one was proposed for the first time), both in identifying CA patients and in discriminating patients according to their Perugini score. Results. Heart/Whole-body ratios proved to be the most accurate (100%) in identifying CA patients. Heart/Pelvis ratio (with soft tissue background correction) offered acceptable accuracy (98%), with the largest area under the curve (AUC) (0.98) in discriminating patients with Perugini ‡ 2. Heart/Contralateral Lung ratio confirmed to be exposed to confounding background noise in case of simultaneous lung uptake. Heart/Skull ratio had the worst performance, with six false-negative patients in ATTR identification. Conclusion. Heart/Whole-body ratios may be robust and effective semi-quantitative indices for the evaluation of CA by means of scintigraphy
2021
14
0
0
Gallini, Chiara; Tutino, Francesca; Martone, Raffaele; Ciaccio, Alfonso; Costanzo, Egidio Natalino; Taborchi, Giulia; Morini, Sofia; Bartolini, Simone; Farsetti, Silvia; Di Mario, Carlo; Perfetto, Federico; Cappelli, Francesco
File in questo prodotto:
File Dimensione Formato  
Gallini 2019_Article_Semi-quantitativeIndicesOfCard.pdf

accesso aperto

Tipologia: Pdf editoriale (Version of record)
Licenza: Tutti i diritti riservati
Dimensione 425.2 kB
Formato Adobe PDF
425.2 kB Adobe PDF

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1150531
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 28
  • ???jsp.display-item.citation.isi??? 29
social impact