Report of 6 patients with celiac disease showing granular IgA deposits at the dermal-epidermal junction despite they did not have dermatitis herpetiformis, but other inflammatory skin diseases

Coeliac disease is an immune-mediated enteropathy driven by gluten, which can be associated with dermatitis herpetiformis. The presence of granular IgA deposits, detected by direct immunofluorescence, is the hallmark of dermatitis herpetiformis; nevertheless, IgA deposits have also been demonstrated in healthy skin of patients with coeliac disease. The main objective of this study was to investigate whether IgA deposits could be found in the skin of patients with coeliac disease who have non-dermatitis herpetiformis inflammatory skin diseases. Direct immunofluorescence was performed on perilesional skin biopsies of 6 patients with coeliac disease with non-dermatitis herpetiformis inflammatory skin diseases and, as control, on 12 non-coeliac patients with inflammatory skin diseases. IgA deposits were found in all of the patients with coeliac disease, but were absent in the control group. In conclusion, IgA deposits may be considered an immunopathological marker for coeliac disease; therefore, patients with coeliac disease showing skin manifestations with positive direct immunofluorescence should be investigated carefully in order to make a differential diagnosis between dermatitis herpetiformis and other non-dermatitis herpetiformis inflammatory skin diseases.

Granular IgA deposits in the skin of patients with Coeliac disease: Is it always dermatitis herpetiformis? / Bonciolini, Veronica*; Antiga, Emiliano; Bianchi, Beatrice; Del Bianco, Elena; Ninci, Alessandra; Maio, Vincenza; Pimpinelli, Nicola; Caproni, Marzia. - In: ACTA DERMATO-VENEREOLOGICA. - ISSN 0001-5555. - STAMPA. - 99:1(2019), pp. 78-83. [10.2340/00015555-3001]

Granular IgA deposits in the skin of patients with Coeliac disease: Is it always dermatitis herpetiformis?

Antiga, Emiliano;Bianchi, Beatrice;Del Bianco, Elena;Ninci, Alessandra;Maio, Vincenza;Pimpinelli, Nicola;Caproni, Marzia
2019

Abstract

Coeliac disease is an immune-mediated enteropathy driven by gluten, which can be associated with dermatitis herpetiformis. The presence of granular IgA deposits, detected by direct immunofluorescence, is the hallmark of dermatitis herpetiformis; nevertheless, IgA deposits have also been demonstrated in healthy skin of patients with coeliac disease. The main objective of this study was to investigate whether IgA deposits could be found in the skin of patients with coeliac disease who have non-dermatitis herpetiformis inflammatory skin diseases. Direct immunofluorescence was performed on perilesional skin biopsies of 6 patients with coeliac disease with non-dermatitis herpetiformis inflammatory skin diseases and, as control, on 12 non-coeliac patients with inflammatory skin diseases. IgA deposits were found in all of the patients with coeliac disease, but were absent in the control group. In conclusion, IgA deposits may be considered an immunopathological marker for coeliac disease; therefore, patients with coeliac disease showing skin manifestations with positive direct immunofluorescence should be investigated carefully in order to make a differential diagnosis between dermatitis herpetiformis and other non-dermatitis herpetiformis inflammatory skin diseases.
2019
99
78
83
Goal 3: Good health and well-being for people
Report of 6 patients with celiac disease showing granular IgA deposits at the dermal-epidermal junction despite they did not have dermatitis herpetiformis, but other inflammatory skin diseases
Bonciolini, Veronica*; Antiga, Emiliano; Bianchi, Beatrice; Del Bianco, Elena; Ninci, Alessandra; Maio, Vincenza; Pimpinelli, Nicola; Caproni, Marzia
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1150624
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