A drug delivery system (DDS) for combined therapy, based on a short oxidized multiwalled carbon nanotube, is reported. It was prepared by exploiting a synthetic approach which allowed loading of two drugs, doxorubicin and metformin, the targeting agent biotin and a radiolabeling tag, to enable labeling with Ga-68 or Cu-64 in order to perform an extensive biodistribution study by PET/CT. The DDS biodistribution profile changes with different administration methods. Once administered at therapeutic doses, the DDS showed a marginal beneficial effect on 4T1 tumor bearing mice, a syngeneic and orthotopic model of triple negative breast cancer, with survival extended by 1 week and 2 days in 20% of the mice. This is encouraging given the aggressiveness of the 4T1 tumor. Furthermore, our DDS was well tolerated, ruling out concerns regarding the toxicity of carbon nanotubes.

Multiwalled carbon nanotubes for combination therapy: a biodistribution and efficacy pilot study / Biagiotti, Giacomo; Pisaneschi, Federica; Gammon, Seth T.; Machetti, Fabrizio; Ligi, Maria Cristina; Giambastiani, Giuliano; Tuci, Giulia; Powell, Emily; Piwnica-Worms, Helen; Pranzini, Erica; Paoli, Paolo; Cicchi, Stefano; Piwnica-Worms, David. - In: JOURNAL OF MATERIALS CHEMISTRY. B. - ISSN 2050-750X. - STAMPA. - -:(2019), pp. 1-10. [10.1039/C8TB03299H]

Multiwalled carbon nanotubes for combination therapy: a biodistribution and efficacy pilot study

Biagiotti, Giacomo;Pisaneschi, Federica;Machetti, Fabrizio;Ligi, Maria Cristina;Giambastiani, Giuliano;Tuci, Giulia;Pranzini, Erica;Paoli, Paolo;Cicchi, Stefano
;
2019

Abstract

A drug delivery system (DDS) for combined therapy, based on a short oxidized multiwalled carbon nanotube, is reported. It was prepared by exploiting a synthetic approach which allowed loading of two drugs, doxorubicin and metformin, the targeting agent biotin and a radiolabeling tag, to enable labeling with Ga-68 or Cu-64 in order to perform an extensive biodistribution study by PET/CT. The DDS biodistribution profile changes with different administration methods. Once administered at therapeutic doses, the DDS showed a marginal beneficial effect on 4T1 tumor bearing mice, a syngeneic and orthotopic model of triple negative breast cancer, with survival extended by 1 week and 2 days in 20% of the mice. This is encouraging given the aggressiveness of the 4T1 tumor. Furthermore, our DDS was well tolerated, ruling out concerns regarding the toxicity of carbon nanotubes.
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Biagiotti, Giacomo; Pisaneschi, Federica; Gammon, Seth T.; Machetti, Fabrizio; Ligi, Maria Cristina; Giambastiani, Giuliano; Tuci, Giulia; Powell, Emily; Piwnica-Worms, Helen; Pranzini, Erica; Paoli, Paolo; Cicchi, Stefano; Piwnica-Worms, David
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2158/1151851
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