The aim of this study was to investigate further the influence of dermorphin (D), a new potent opioid peptide (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2), on the functional activity of the pituitary-adrenocortical system in man. Six normal men were treated with oral metyrapone to stimulate the secretion of ACTH, beta-lipotropin, and beta-endorphin. In these subjects, significant suppression of metyrapone-evoked release of ACTH and related peptides occurred during D infusion (5.5 micrograms/kg X min for 30 min) compared with that during saline infusion. These results indicate that D can induce a significant decline in plasma levels of ACTH, beta-lipotropin, and beta-endorphin, the major circulating peptides from the C-terminal part of proopiocortin, and suggest that opioid peptides may be involved in the control of the functional activity of pituitary-adrenocortical activity in man.
Dermorphin reduces the metyrapone-evoked release of adrenocorticotropin, β-endorphin, and β-lipotropin in man / Uberti, Ettore C. Degli*; Petraglia, Felice; Trasforini, Giorgio; Salvadori, Severo; Margutti, Angelo; Bianconi, Michele; Teodori, Valeria; Facchinetti, Fabio; Tomatis, Roberto; Genazzani, Andrea R.; Pansini, Raffaele. - In: THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. - ISSN 0021-972X. - ELETTRONICO. - 61:(1985), pp. 1018-1022. [10.1210/jcem-61-6-1018]
Dermorphin reduces the metyrapone-evoked release of adrenocorticotropin, β-endorphin, and β-lipotropin in man
Petraglia, Felice;
1985
Abstract
The aim of this study was to investigate further the influence of dermorphin (D), a new potent opioid peptide (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2), on the functional activity of the pituitary-adrenocortical system in man. Six normal men were treated with oral metyrapone to stimulate the secretion of ACTH, beta-lipotropin, and beta-endorphin. In these subjects, significant suppression of metyrapone-evoked release of ACTH and related peptides occurred during D infusion (5.5 micrograms/kg X min for 30 min) compared with that during saline infusion. These results indicate that D can induce a significant decline in plasma levels of ACTH, beta-lipotropin, and beta-endorphin, the major circulating peptides from the C-terminal part of proopiocortin, and suggest that opioid peptides may be involved in the control of the functional activity of pituitary-adrenocortical activity in man.I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.