We reported a series of amide-based hybrid compounds incorporating 6- and 7-substituted coumarins and some NSAIDs as agents for the management of RA. [1] These derivatives were proved to exert remarkable anti-inflammatory action in spite of non-significant amide-bond cleavage in vivo. [1-3] As a rational development, we report herein all such derivatives ester bioisosters to investigate the contribution of a more cleavable linker in terms of plasma stability
STABILITY STUDY IN PLASMA OF NOVEL ESTER-LINKED NSAID - CARBONIC ANHYDRASE INHIBITOR HYBRIDS / Silvia Bua; Marta Menicatti; Paola Gratteri; Alessio Nocentini; Claudiu T. Supuran; Gian Luca Bartolucci. - ELETTRONICO. - (2018), pp. 841-842. (Intervento presentato al convegno XXII International Mass Spectrometry Conference tenutosi a Florence (Italy) nel August 26-31, 2018).
STABILITY STUDY IN PLASMA OF NOVEL ESTER-LINKED NSAID - CARBONIC ANHYDRASE INHIBITOR HYBRIDS
Silvia Bua;Marta Menicatti;Paola Gratteri;Gian Luca Bartolucci;
2018
Abstract
We reported a series of amide-based hybrid compounds incorporating 6- and 7-substituted coumarins and some NSAIDs as agents for the management of RA. [1] These derivatives were proved to exert remarkable anti-inflammatory action in spite of non-significant amide-bond cleavage in vivo. [1-3] As a rational development, we report herein all such derivatives ester bioisosters to investigate the contribution of a more cleavable linker in terms of plasma stability
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