The separation of a mixtures of isomers by chromatography generally requires lot of time and it is isomers pair-specific. To overcome this issue, LC-MS/MS methods, together with a mathematical algorithm that is able to identify the isomers present in the sample without their chromatographic separation, were developed [1-2]. This approach was applied to MS/MS acquisitions obtained with both triple quadrupole and ion trap mass analyzers.
APPLICATION OF LINEAR EQUATIONS DECONVOLUTION ANALYSIS (LEDA) ALGORITHM IN ION TRAP MASS SPECTROMETRY: RESOLUTION OF ISOMERIC PAIRS OF CARBONIC ANHYDRASE AND CYCLOOXYGENASE HYBRIDS INHIBITORS / Donato Squillaci; Marta Menicatti; Silvia Bua; Claudiu T. Supuran; Gian Luca Bartolucci. - ELETTRONICO. - (2018), pp. 846-847. (Intervento presentato al convegno XXII International Mass Spectrometry Conference tenutosi a Florence (Italy) nel August 26-31, 2018).
APPLICATION OF LINEAR EQUATIONS DECONVOLUTION ANALYSIS (LEDA) ALGORITHM IN ION TRAP MASS SPECTROMETRY: RESOLUTION OF ISOMERIC PAIRS OF CARBONIC ANHYDRASE AND CYCLOOXYGENASE HYBRIDS INHIBITORS
Donato Squillaci;Marta Menicatti;Silvia Bua;Gian Luca Bartolucci
2018
Abstract
The separation of a mixtures of isomers by chromatography generally requires lot of time and it is isomers pair-specific. To overcome this issue, LC-MS/MS methods, together with a mathematical algorithm that is able to identify the isomers present in the sample without their chromatographic separation, were developed [1-2]. This approach was applied to MS/MS acquisitions obtained with both triple quadrupole and ion trap mass analyzers.
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