The involvement of phosphoinositides (PI) signal transduction pathway and related molecules, such as the Phosphoinositide-specific Phospholipase C (PI-PLC) enzymes, in the pathophysiology of mood disorders is corroborated by a number of recent evidences. Our previous works identified the deletion of PLCB1 gene, which codifies for the PI-PLC beta1 enzyme, in 4 out 15 patients affected with schizophrenia, and no deletion both in major depression affected patients and in normal controls. By using interphase fluorescent in situ hybridization methodology, we analyzed PLCB1 in paraffin embedded samples of orbito-frontal cortex of 15 patients affected with bipolar disorder. Deletion of PLCB1 was identified in one female patient.
Phosphoinositide-specific Phospholipase C b1 gene deletion in bipolar disorder affected patient / V.R. Lo Vasco; L. Longo; P. Polonia. - In: JOURNAL OF CELL COMMUNICATION AND SIGNALING. - ISSN 1873-9601. - STAMPA. - 1:(2013), pp. 25-29. [10.1007/s12079-012-0182-2]
Phosphoinositide-specific Phospholipase C b1 gene deletion in bipolar disorder affected patient
V.R. Lo Vasco;
2013
Abstract
The involvement of phosphoinositides (PI) signal transduction pathway and related molecules, such as the Phosphoinositide-specific Phospholipase C (PI-PLC) enzymes, in the pathophysiology of mood disorders is corroborated by a number of recent evidences. Our previous works identified the deletion of PLCB1 gene, which codifies for the PI-PLC beta1 enzyme, in 4 out 15 patients affected with schizophrenia, and no deletion both in major depression affected patients and in normal controls. By using interphase fluorescent in situ hybridization methodology, we analyzed PLCB1 in paraffin embedded samples of orbito-frontal cortex of 15 patients affected with bipolar disorder. Deletion of PLCB1 was identified in one female patient.File | Dimensione | Formato | |
---|---|---|---|
10.1007_s12079-012-0182-2.pdf
Accesso chiuso
Dimensione
362.51 kB
Formato
Adobe PDF
|
362.51 kB | Adobe PDF | Richiedi una copia |
10.1007_s12079-012-0182-2.pdf
Accesso chiuso
Dimensione
362.51 kB
Formato
Adobe PDF
|
362.51 kB | Adobe PDF | Richiedi una copia |
I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.