Aberrant DNA methylation is very common in bladder cancer (BC) pathogenesis and progression. These epigenetic alterations are detectable in voided urine and might be useful as non-invasive urinary biomarkers for the early detection of BC. Our multi-centric study supports the promise of epigenetic urinary markers in non-invasively detecting bladder cancer and discriminating between grades. Validation in different clinical settings including patients with hematuria, bladder cancer surveillance or screening in high-risk populations is warranted to support its utility.
A non-invasive urine-based methylation biomarker panel to detect bladder cancer and discriminate cancer grade / Hermanns, T., Savio, A.J., Olkhov-Mitsel, E., Mari, A., Saba, K., Bhindi, B., Gill, B., Sykes, J., Kuk, C., Poyet, C., Wild, P.J., Noon, A., Bashir, S., Juvet, T., Rendon, R.A., Waltregny, D., Van Der Kwast, T., Finelli, A., Kulkarni, G.S., Fleshner, N.E., et al.. - In: EUROPEAN UROLOGY. SUPPLEMENTS. - ISSN 1569-9056. - ELETTRONICO. - 18:(2019), pp. e314-e314. [10.1016/S1569-9056(19)30228-3]
A non-invasive urine-based methylation biomarker panel to detect bladder cancer and discriminate cancer grade
Mari, A.;
2019
Abstract
Aberrant DNA methylation is very common in bladder cancer (BC) pathogenesis and progression. These epigenetic alterations are detectable in voided urine and might be useful as non-invasive urinary biomarkers for the early detection of BC. Our multi-centric study supports the promise of epigenetic urinary markers in non-invasively detecting bladder cancer and discriminating between grades. Validation in different clinical settings including patients with hematuria, bladder cancer surveillance or screening in high-risk populations is warranted to support its utility.
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