ObjectivesTo evaluate the efficacy and safety of FOLFOX-4 combination chemotherapy, followed by leucovorin (LV)/bolus and continuous infusion 5-fluorouracil (5-FU) as maintenance chemotherapy in elderly (≥. 75. years) patients with advanced oesophagogastric cancer with impaired performance status (PS). Materials and MethodsPatients with a PS score >. 1 were included in this study. PS evaluations were performed by a geriatrician and two medical oncologists. FOLFOX-4 consisted of oxaliplatin concurrently with LV/bolus and continuous infusion 5-FU every 2. weeks. After a maximum of six FOLFOX-4. cycles, patients with no evidence of disease progression received maintenance treatment with LV/bolus and continuous infusion 5-FU every 2. weeks until disease progression or unacceptable toxicity. ResultsThirty-eight patients were enrolled in this study. Of these, 32 (84.2%) patients had a PS score of 2 and six (15.7%) patients had a PS score of 3. After completion of FOLFOX-4, 18 (47.3%) patients achieved a partial response and 14 (36.8%) patients had stable disease. Thirty-two patients (84.2%) received maintenance chemotherapy for a median of eight cycles (range one to 26. cycles). The 6-month disease-control rate was 47.3% [95% confidence interval (CI) 30.9-64.1]. The median progression-free survival was 5.9. months (95% CI 4.7-6.8) and the median overall survival was 9.6. months (95% CI 8.1-11.7). Grade 3 neutropenia occurred in six patients (15.7%), and Grade 3 anaemia and thrombocytopenia occurred in two patients (5.2%). ConclusionFOLFOX-4 followed by LV/bolus and continuous infusion 5-FU as maintenance chemotherapy seems to be an active and well-tolerated first-line treatment strategy for elderly patients with advanced oesophagogastric cancer and impaired PS.

Treatment of advanced oesophagogastric cancer with FOLFOX-4 regimen followed by leucovorin/bolus and continuous infusion 5-FU as maintenance chemotherapy in patients aged ≥ 75 years with impaired performance status / PETRIOLI, ROBERTO; Francini, Edoardo; ROVIELLO, FRANCO; MARRELLI, DANIELE; MIANO, SALVATORA TINDARA; FIASCHI, ANNA IDA; LAERA, LETIZIA; BELLINI, MARCO ANTONIO; ROVIELLO, GIANDOMENICO. - In: JOURNAL OF GERIATRIC ONCOLOGY. - ISSN 1879-4068. - STAMPA. - 6:(2015), pp. 380-386. [10.1016/j.jgo.2015.06.002]

Treatment of advanced oesophagogastric cancer with FOLFOX-4 regimen followed by leucovorin/bolus and continuous infusion 5-FU as maintenance chemotherapy in patients aged ≥ 75 years with impaired performance status

Francini, Edoardo;LAERA, LETIZIA;ROVIELLO, GIANDOMENICO
2015

Abstract

ObjectivesTo evaluate the efficacy and safety of FOLFOX-4 combination chemotherapy, followed by leucovorin (LV)/bolus and continuous infusion 5-fluorouracil (5-FU) as maintenance chemotherapy in elderly (≥. 75. years) patients with advanced oesophagogastric cancer with impaired performance status (PS). Materials and MethodsPatients with a PS score >. 1 were included in this study. PS evaluations were performed by a geriatrician and two medical oncologists. FOLFOX-4 consisted of oxaliplatin concurrently with LV/bolus and continuous infusion 5-FU every 2. weeks. After a maximum of six FOLFOX-4. cycles, patients with no evidence of disease progression received maintenance treatment with LV/bolus and continuous infusion 5-FU every 2. weeks until disease progression or unacceptable toxicity. ResultsThirty-eight patients were enrolled in this study. Of these, 32 (84.2%) patients had a PS score of 2 and six (15.7%) patients had a PS score of 3. After completion of FOLFOX-4, 18 (47.3%) patients achieved a partial response and 14 (36.8%) patients had stable disease. Thirty-two patients (84.2%) received maintenance chemotherapy for a median of eight cycles (range one to 26. cycles). The 6-month disease-control rate was 47.3% [95% confidence interval (CI) 30.9-64.1]. The median progression-free survival was 5.9. months (95% CI 4.7-6.8) and the median overall survival was 9.6. months (95% CI 8.1-11.7). Grade 3 neutropenia occurred in six patients (15.7%), and Grade 3 anaemia and thrombocytopenia occurred in two patients (5.2%). ConclusionFOLFOX-4 followed by LV/bolus and continuous infusion 5-FU as maintenance chemotherapy seems to be an active and well-tolerated first-line treatment strategy for elderly patients with advanced oesophagogastric cancer and impaired PS.
2015
6
380
386
Goal 3: Good health and well-being for people
PETRIOLI, ROBERTO; Francini, Edoardo; ROVIELLO, FRANCO; MARRELLI, DANIELE; MIANO, SALVATORA TINDARA; FIASCHI, ANNA IDA; LAERA, LETIZIA; BELLINI, MARCO...espandi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1156830
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