Water-dispersible dextran-based single-chain polymer nanoparticles (SCPNs) were prepared in aqueous media and under mild conditions. Radiolabeling of the resulting biocompatible materials allowed the study of lung deposition of aqueous aerosols after intratracheal nebulization by means of single-photon emission computed tomography (SPECT), demonstrating their potential use as imaging contrast agents.
Synthesis and functionalization of dextran-based single-chain nanoparticles in aqueous media / Gracia, R.; Marradi, M.; Cossío, U.; Benito, A.; Pérez-San Vicente, A.; Gómez-Vallejo, V.; Grande, H.-J.; Llop, J.; Loinaz, I.. - In: JOURNAL OF MATERIALS CHEMISTRY. B. - ISSN 2050-750X. - ELETTRONICO. - 5:(2017), pp. 1143-1147. [10.1039/C6TB02773C]
Synthesis and functionalization of dextran-based single-chain nanoparticles in aqueous media
Marradi, M.;
2017
Abstract
Water-dispersible dextran-based single-chain polymer nanoparticles (SCPNs) were prepared in aqueous media and under mild conditions. Radiolabeling of the resulting biocompatible materials allowed the study of lung deposition of aqueous aerosols after intratracheal nebulization by means of single-photon emission computed tomography (SPECT), demonstrating their potential use as imaging contrast agents.
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