Gold manno‐glyconanoparticles displaying different densities of linear and branched mannose oligosaccharides acted as inhibitors of DC‐SIGN‐mediated HIV trans‐infection of human activated peripheral blood mononuclear cells. Presentation of simple linear di‐, tri‐, and tetraoligosaccharides on the nanoclusters resulted in efficiencies similar to those observed for complex branched penta‐ and heptamannosides.
Multivalent manno-glyconanoparticles inhibit DC-SIGN-mediated HIV-1 trans-infection of human T cells / Martínez-Avila, Olga; Bedoya, Luis M; Marradi, Marco; Clavel, Caroline; Alcamí, José; Penadés, Soledad. - In: CHEMBIOCHEM. - ISSN 1439-4227. - ELETTRONICO. - 10:(2009), pp. 1806-1809. [10.1002/cbic.200900294]
Multivalent manno-glyconanoparticles inhibit DC-SIGN-mediated HIV-1 trans-infection of human T cells
Marradi, Marco;
2009
Abstract
Gold manno‐glyconanoparticles displaying different densities of linear and branched mannose oligosaccharides acted as inhibitors of DC‐SIGN‐mediated HIV trans‐infection of human activated peripheral blood mononuclear cells. Presentation of simple linear di‐, tri‐, and tetraoligosaccharides on the nanoclusters resulted in efficiencies similar to those observed for complex branched penta‐ and heptamannosides.
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