The present review focuses on adipocytes-released peptides known to be involved in the control of gastrointestinal motility, acting both centrally and peripherally. Thus, four peptides have been taken into account: leptin, adiponectin, nesfatin-1, and apelin. The discussion of the related physiological or pathophysiological roles, based on the most recent findings, is intended to underlie the close interactions among adipose tissue, central nervous system, and gastrointestinal tract. The better understanding of this complex network, as gastrointestinal motor responses represent peripheral signals involved in the regulation of food intake through the gut-brain axis, may also furnish a cue for the development of either novel therapeutic approaches in the treatment of obesity and eating disorders or potential diagnostic tools.

Adipocytes-released Peptides Involved in the Control of Gastrointestinal Motility / Idrizaj E, Garella R, Squecco R, Baccari MC.. - In: CURRENT PROTEIN & PEPTIDE SCIENCE. - ISSN 1389-2037. - ELETTRONICO. - 20:(2019), pp. 614-629. [10.2174/1389203720666190121115356]

Adipocytes-released Peptides Involved in the Control of Gastrointestinal Motility

Idrizaj E;Garella R;Squecco R;Baccari MC.
2019

Abstract

The present review focuses on adipocytes-released peptides known to be involved in the control of gastrointestinal motility, acting both centrally and peripherally. Thus, four peptides have been taken into account: leptin, adiponectin, nesfatin-1, and apelin. The discussion of the related physiological or pathophysiological roles, based on the most recent findings, is intended to underlie the close interactions among adipose tissue, central nervous system, and gastrointestinal tract. The better understanding of this complex network, as gastrointestinal motor responses represent peripheral signals involved in the regulation of food intake through the gut-brain axis, may also furnish a cue for the development of either novel therapeutic approaches in the treatment of obesity and eating disorders or potential diagnostic tools.
2019
20
614
629
Goal 3: Good health and well-being for people
Idrizaj E, Garella R, Squecco R, Baccari MC.
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1159247
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