The present invention comprises a process for preparing water-dispersable single-chain polymeric nanoparticles, which comprises cross-linking a polymer having a solubility equal to or higher than 100 mg per litre of water, and an amount of complementary reactive groups comprised from 5 to 60 molar % of the total amount of monomer units present in the polymer chain; with a crosslinking agent having crosslinkable groups; at a temperature comprised from 20 to 25°C in the absence of a catalyst; to obtain water-dispersable conjugates and compositions containing the nanoparticle; and the use thereof.
A PROCESS FOR PREPARING WATER-DISPERSIBLE SINGLE-CHAIN POLYMERIC NANOPARTICLES / AIERTZA OTXOTORENA, Miren Karmele; SÁNCHEZ ABELLA, Laura; BENITO COLLADO, Ana Belén; LOINAZ BORDONABE, Iraida; CABAÑERO, Germán; GRANDE, Hans-Jürgen; MARRADI, Marco; GRACIA ESPAÑA, Raquel.. - (2015).
A PROCESS FOR PREPARING WATER-DISPERSIBLE SINGLE-CHAIN POLYMERIC NANOPARTICLES
MARRADI, Marco;
2015
Abstract
The present invention comprises a process for preparing water-dispersable single-chain polymeric nanoparticles, which comprises cross-linking a polymer having a solubility equal to or higher than 100 mg per litre of water, and an amount of complementary reactive groups comprised from 5 to 60 molar % of the total amount of monomer units present in the polymer chain; with a crosslinking agent having crosslinkable groups; at a temperature comprised from 20 to 25°C in the absence of a catalyst; to obtain water-dispersable conjugates and compositions containing the nanoparticle; and the use thereof.
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