In vitro investigation on the cytotoxic effects of four nanosystems and a free antimicrobial peptide (AMP) on a human lung cell line (A549) was carried out in a realistic test environment using the P.R.I.T.® ALI technology. Test substances as well as vehicle, positive (CuSO4) and negative (Lactose) controls were aerosolized. The free antimicrobial peptide displayed the strongest toxicity of all test substances. Protective effects of novel nanosystems depend on the antibiotic/nanocompound combination.
Cytotoxicity testing of therapeutic nanosystems for pulmonary infection using an air-lifted interphase in-vitro test system / Knebel, J.; Ritter, D.; Niehof, M.; Hansen, T.; Strandh, M.; Falciani, C.; Flores, M.; te Welscher, Y.; van Nostrum, C.; Gracia, R.; Marradi, M.; Loinaz, I.. - In: TOXICOLOGY LETTERS. - ISSN 0378-4274. - ELETTRONICO. - 295:(2018), pp. S69-S69. (Intervento presentato al convegno 54th Congress of the European Societies of Toxicology (EUROTOX 2018) TOXICOLOGY OUT OF THE BOX tenutosi a Brussels, Belgium, nel 2nd – 5th of September, 2018) [10.1016/j.toxlet.2018.06.520].
Cytotoxicity testing of therapeutic nanosystems for pulmonary infection using an air-lifted interphase in-vitro test system
Marradi, M.;
2018
Abstract
In vitro investigation on the cytotoxic effects of four nanosystems and a free antimicrobial peptide (AMP) on a human lung cell line (A549) was carried out in a realistic test environment using the P.R.I.T.® ALI technology. Test substances as well as vehicle, positive (CuSO4) and negative (Lactose) controls were aerosolized. The free antimicrobial peptide displayed the strongest toxicity of all test substances. Protective effects of novel nanosystems depend on the antibiotic/nanocompound combination.
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