Gold nanoparticles (GNPs) decorated with glycans improve dendritic cells (DC) uptake, antigen-presentation and T-cells cross-talk. HIV-1-peptides loaded onto GNPs bearing high-mannoside (HM)-type oligosaccharides are presented to autologous T-cells from HIV-1 patients, increasing HIV-specific CD4+ and CD8+ T-cell proliferation and inducing highly functional cytokine secretion compared with HIV-peptides alone. Thus, co-delivery of HIV-1 antigens and HM by GNPs to dendritic cells enhances DC-presentation and improves highly functional HIV-specific cellular immune responses from HIV+ patients. This data would support the idea of combining GNPs bearing antigens and glyco-compounds as HIV vaccines.
Loading Dendritic Cells with Gold Nanoparticles (GNPs) Bearing HIV-peptides and Mannosides Enhance HIV-specific T Cell Responses / Núria Climent, Isabel García, Marco Marradi, Fabrizio Chiodo, Laia Miralles, María José Maleno, José María Gatell, Felipe García, Luis M. Liz-Marzán, Soledad Penadés, Montserrat Plana. - In: AIDS RESEARCH AND HUMAN RETROVIRUSES. - ISSN 0889-2229. - ELETTRONICO. - 32:(2016), pp. 404-404. (Intervento presentato al convegno HIV Research for Prevention Meeting, HIVR4P tenutosi a Chicago, USA nel 17-20 October, 2016) [10.1089/aid.2016.5000.abstracts].
Loading Dendritic Cells with Gold Nanoparticles (GNPs) Bearing HIV-peptides and Mannosides Enhance HIV-specific T Cell Responses
Marco Marradi;
2016
Abstract
Gold nanoparticles (GNPs) decorated with glycans improve dendritic cells (DC) uptake, antigen-presentation and T-cells cross-talk. HIV-1-peptides loaded onto GNPs bearing high-mannoside (HM)-type oligosaccharides are presented to autologous T-cells from HIV-1 patients, increasing HIV-specific CD4+ and CD8+ T-cell proliferation and inducing highly functional cytokine secretion compared with HIV-peptides alone. Thus, co-delivery of HIV-1 antigens and HM by GNPs to dendritic cells enhances DC-presentation and improves highly functional HIV-specific cellular immune responses from HIV+ patients. This data would support the idea of combining GNPs bearing antigens and glyco-compounds as HIV vaccines.
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