Objective: To evaluate the neuroendocrine effect of naltrexone in the long-term treatment of polycystic ovary syndrome. Methods: The chronobiological secretory characteristics of the pituitary hormones FSH, LH, PRL, and cortisol were investigated over a period of 8 hours in a group of polycystic ovary syndrome patients before and after treatment with naltrexone (50 mg per os daily for 28 days). Results: No significant changes in integrated LH mean values and mean LH pulse frequency were found, whereas the mean LH pulse amplitude was significantly lower
Long-term naltrexone treatment modifies luteinizing hormone secretory amplitude in polycistic ovary syndrome / Nappi, R.E.*; Petraglia, F.; Bacchi-Modena, A.; Benassi, L.; Genazzani, A.D.; Comitini, G.; Nappi, C.; Genazzani, A.R.. - In: ITALIAN JOURNAL OF GYNAECOLOGY & OBSTETRICS. - ISSN 1121-8339. - ELETTRONICO. - 5:(1993), pp. 64-68.
Long-term naltrexone treatment modifies luteinizing hormone secretory amplitude in polycistic ovary syndrome
Petraglia, F.;
1993
Abstract
Objective: To evaluate the neuroendocrine effect of naltrexone in the long-term treatment of polycystic ovary syndrome. Methods: The chronobiological secretory characteristics of the pituitary hormones FSH, LH, PRL, and cortisol were investigated over a period of 8 hours in a group of polycystic ovary syndrome patients before and after treatment with naltrexone (50 mg per os daily for 28 days). Results: No significant changes in integrated LH mean values and mean LH pulse frequency were found, whereas the mean LH pulse amplitude was significantly lower
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