Eleven patients with presenile Alzheimer type dementia (ATD) were treated with N-terminal ACTH fragments for 14 days. No change in cognitive functions was observed during the treatment. A significant increase in CSF beta-endorphin (beta-EP) levels was found, while ACTH and beta-lipoprotein remain unaffected. The possibility that ACTH and its moieties could interfere with beta-EP activities in CNS is discussed
Nâterminal ACTH fragments increase the CSF βâEP content in Alzheimer type dementia / Nappi, G.; Facchinetti, F.; Martignoni, E.; Petraglia, F.; Sinforiani, E.; Bono, G.; Genazzani, A.R.. - In: ACTA NEUROLOGICA SCANDINAVICA. - ISSN 0001-6314. - ELETTRONICO. - 78:(1988), pp. 146-151. [10.1111/j.1600-0404.1988.tb03636.x]
Nâterminal ACTH fragments increase the CSF βâEP content in Alzheimer type dementia
Facchinetti, F.;Petraglia, F.
;
1988
Abstract
Eleven patients with presenile Alzheimer type dementia (ATD) were treated with N-terminal ACTH fragments for 14 days. No change in cognitive functions was observed during the treatment. A significant increase in CSF beta-endorphin (beta-EP) levels was found, while ACTH and beta-lipoprotein remain unaffected. The possibility that ACTH and its moieties could interfere with beta-EP activities in CNS is discussed
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